TY - JOUR
T1 - Identification of a Risk Profile for New-Onset Diabetes after Acute Pancreatitis
AU - Firkins, Stephen A.
AU - Hart, Phil A.
AU - Papachristou, Georgios I.
AU - Lara, Luis F.
AU - Cruz-Monserrate, Zobeida
AU - Hinton, Alice
AU - Conwell, Darwin L.
AU - Bradley, David P.
AU - Krishna, Somashekar G.
N1 - Funding Information:
Key Words: diabetes, acute pancreatitis, population database, metabolic syndrome From the *Department of Internal Medicine, †Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center; ‡Division of Biostatistics, College of Public Health, The Ohio State University; and §Division of Endocrinology and Metabolism, The Ohio State University Wexner Medical Center, Columbus, OH. Received for publication July 10, 2020; accepted April 1, 2021. Address correspondence to: Somashekar G. Krishna, MD, MPH, FASGE, AGAF, Sections of Pancreatic Disorders and Advanced Endoscopy, Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, 395 W. 12th Avenue, Suite 262, Columbus, OH 43210 (e‐mail: [email protected]). All authors have approved the final version of this article. Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award number U01DK108327 (P.A.H., L.F.L., Z.C.-M., D.L.C., and S.G.K.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors declare no conflict of interest. Study concept and design: S.A.F., A.H., and S.G.K.; acquisition of data: S.A.F. and A.H.; statistical analysis: A.H.; analysis and interpretation of data: S.A.F., P.A.H., A.H., S.G.K.; drafting of manuscript: S.A.F., P.A.H., D.P.B., S.G.K.; critical revision of manuscript for important intellectual content: S.A.F., P.A.H., G.I.P., L.F.L., Z.C.-M., A.H., D.L.C., D.P.B., and S.G.K.; study supervision and guarantor: S.G.K. Supplemental digital contents are available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.pancreasjournal.com). Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/MPA.0000000000001818
Funding Information:
Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award number U01DK108327 (P.A.H., L.F.L., Z.C.-M., D.L.C., and S.G.K.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Objectives There is a paucity of studies evaluating predictors of new-onset diabetes mellitus (DM) after acute pancreatitis (AP-related DM). We used a population-based database to evaluate predictors of AP-related DM. Methods The Nationwide Readmissions Database (2010-2014) was used to identify all nondiabetic adults with an index primary diagnosis of AP. Multiple exclusions were applied to identify cohorts with and without AP-related DM. A case-control study was conducted to identify risk factors for developing AP-related DM within the calendar year. Results We identified 2510 subjects with AP-related DM and 40,308 controls with AP who did not develop DM. Multivariable analysis revealed that increasing age (50-64 years; adjusted odds ratio [aOR], 1.35; 95% confidence interval [CI], 1.14-1.60), male sex (aOR, 1.2; 95% CI, 1.03-1.40), lowest income quartile (aOR, 1.48; 95% CI, 1.18-1.84), Elixhauser comorbidity index of 3 or higher (aOR, 1.47; 95% CI, 1.23-1.75), components of metabolic syndrome (aOR, 2.12; 95% CI, 1.21-3.70), severe AP (aOR, 1.60; 95% CI, 1.34-1.90), and recurrent AP (aOR, 1.46; 95% CI, 1.24-1.72) were independently associated with increased risk of AP-related DM. Conclusions These population-level variables predictive of developing AP-related DM can potentially identify patients who may benefit from closer follow-up, intensive education, and implementation of preventative strategies.
AB - Objectives There is a paucity of studies evaluating predictors of new-onset diabetes mellitus (DM) after acute pancreatitis (AP-related DM). We used a population-based database to evaluate predictors of AP-related DM. Methods The Nationwide Readmissions Database (2010-2014) was used to identify all nondiabetic adults with an index primary diagnosis of AP. Multiple exclusions were applied to identify cohorts with and without AP-related DM. A case-control study was conducted to identify risk factors for developing AP-related DM within the calendar year. Results We identified 2510 subjects with AP-related DM and 40,308 controls with AP who did not develop DM. Multivariable analysis revealed that increasing age (50-64 years; adjusted odds ratio [aOR], 1.35; 95% confidence interval [CI], 1.14-1.60), male sex (aOR, 1.2; 95% CI, 1.03-1.40), lowest income quartile (aOR, 1.48; 95% CI, 1.18-1.84), Elixhauser comorbidity index of 3 or higher (aOR, 1.47; 95% CI, 1.23-1.75), components of metabolic syndrome (aOR, 2.12; 95% CI, 1.21-3.70), severe AP (aOR, 1.60; 95% CI, 1.34-1.90), and recurrent AP (aOR, 1.46; 95% CI, 1.24-1.72) were independently associated with increased risk of AP-related DM. Conclusions These population-level variables predictive of developing AP-related DM can potentially identify patients who may benefit from closer follow-up, intensive education, and implementation of preventative strategies.
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U2 - 10.1097/MPA.0000000000001818
DO - 10.1097/MPA.0000000000001818
M3 - Article
C2 - 34016890
AN - SCOPUS:85108021451
SN - 0885-3177
VL - 50
SP - 696
EP - 703
JO - Pancreas
JF - Pancreas
IS - 5
ER -