Identification of Candidate B-Lymphoma Genes by Cross-Species Gene Expression Profiling

Van S. Tompkins, Seong Su Han, Alicia Olivier, Sergei Syrbu, Thomas Bair, Anna Button, Laura Jacobus, Zebin Wang, Samuel Lifton, Pradip Raychaudhuri, Herbert C. Morse, George Weiner, Brian Link, Brian J. Smith, Siegfried Janz

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Comparative genome-wide expression profiling of malignant tumor counterparts across the human-mouse species barrier has a successful track record as a gene discovery tool in liver, breast, lung, prostate and other cancers, but has been largely neglected in studies on neoplasms of mature B-lymphocytes such as diffuse large B cell lymphoma (DLBCL) and Burkitt lymphoma (BL). We used global gene expression profiles of DLBCL-like tumors that arose spontaneously in Myc-transgenic C57BL/6 mice as a phylogenetically conserved filter for analyzing the human DLBCL transcriptome. The human and mouse lymphomas were found to have 60 concordantly deregulated genes in common, including 8 genes that Cox hazard regression analysis associated with overall survival in a published landmark dataset of DLBCL. Genetic network analysis of the 60 genes followed by biological validation studies indicate FOXM1 as a candidate DLBCL and BL gene, supporting a number of studies contending that FOXM1 is a therapeutic target in mature B cell tumors. Our findings demonstrate the value of the "mouse filter" for genomic studies of human B-lineage neoplasms for which a vast knowledge base already exists.

Original languageEnglish (US)
Article numbere76889
JournalPloS one
Issue number10
StatePublished - Oct 9 2013

All Science Journal Classification (ASJC) codes

  • General


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