Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay

Keyphrases

• High-throughput Screening 100%
• Sigma Factor 100%
• High-throughput Screening Assays 100%
• Small Molecules 66%
• Cell Envelope 66%
• Cyclic Peptide 66%
• Alternative sigma Factor 66%
• Yellow Fluorescent Protein 66%
• Gram-negative Pathogens 33%
• Gram-negative Bacteria 33%
• Antibiotics 33%
• Virulence 33%
• Transcription in Vitro 33%
• Escherichia Coli Strains 33%
• Reporter Strain 33%
• Biological Assay 33%
• Activity Assay 33%
• Biochemical Characterization 33%
• RNA Polymerase Holoenzyme 33%
• E-activities 33%
• Negative Regulation 33%
• Pathway Inhibitors 33%
• Antibiotic Development 33%
• Stress Response Pathways 33%

Immunology and Microbiology

• Sigma Factor 100%
• High Throughput Screening 100%
• Infectious Agent 66%
• Antimicrobial Agent 66%
• Cyclic Peptide 66%
• Escherichia coli 33%
• Gram-Negative Bacteria 33%
• RNA Polymerase 33%
• In Vitro 33%