Identification of mycobacterium genavense in a diana monkey (cercopithecus diana) by polymerase chain reaction and high-performance liquid chromatography

Kathleen M. Kelly; Allison N. Wack; Dan Bradway; Brian W. Simons; Ellen Bronson; Gerard Osterhout; Nicole M. Parrish; Richard J. Montali

doi:10.1638/2013-0246R2.1

Identification of mycobacterium genavense in a diana monkey (cercopithecus diana) by polymerase chain reaction and high-performance liquid chromatography

Kathleen M. Kelly, Allison N. Wack, Dan Bradway, Brian W. Simons, Ellen Bronson, Gerard Osterhout, Nicole M. Parrish, Richard J. Montali

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A 25-yr-old Diana monkey (Cercopithecus diana) with a 1.5-yr history of chronic colitis and diarrhea was found to have disseminated granulomatous disease with intralesional acid fast bacilli. Bacilli were identified as Mycobacterium genavense by polymerase chain reaction, sequencing of the 16S-23S ribosomal RNA intergenic spacer (ITS) gene, and mycolic acid analysis by high-performance liquid chromatography. Mycobacterium genavense is a common cause of mycobacteriosis in free-ranging and captive birds. In addition, recognition of opportunistic infection in human immunodeficiency virus-positive patients is increasing. Disease manifestations of M. genavense are similar to Mycobacterium avium complex (MAC) and include fever, wasting, and diarrhea with disseminated disease. Similar clinical signs and lesions were observed in this monkey. Mycobacterium genavense should be considered as a differential for disseminated mycobacterial disease in nonhuman primates as this agent can mimic MAC and related mycobacteria.

Original language	English (US)
Pages (from-to)	339-344
Number of pages	6
Journal	Journal of Zoo and Wildlife Medicine
Volume	46
Issue number	2
DOIs	https://doi.org/10.1638/2013-0246R2.1
State	Published - Jun 1 2015

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Animal Science and Zoology
General Veterinary

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10.1638/2013-0246R2.1

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Kelly, K. M., Wack, A. N., Bradway, D., Simons, B. W., Bronson, E., Osterhout, G., Parrish, N. M., & Montali, R. J. (2015). Identification of mycobacterium genavense in a diana monkey (cercopithecus diana) by polymerase chain reaction and high-performance liquid chromatography. Journal of Zoo and Wildlife Medicine, 46(2), 339-344. https://doi.org/10.1638/2013-0246R2.1

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abstract = "A 25-yr-old Diana monkey (Cercopithecus diana) with a 1.5-yr history of chronic colitis and diarrhea was found to have disseminated granulomatous disease with intralesional acid fast bacilli. Bacilli were identified as Mycobacterium genavense by polymerase chain reaction, sequencing of the 16S-23S ribosomal RNA intergenic spacer (ITS) gene, and mycolic acid analysis by high-performance liquid chromatography. Mycobacterium genavense is a common cause of mycobacteriosis in free-ranging and captive birds. In addition, recognition of opportunistic infection in human immunodeficiency virus-positive patients is increasing. Disease manifestations of M. genavense are similar to Mycobacterium avium complex (MAC) and include fever, wasting, and diarrhea with disseminated disease. Similar clinical signs and lesions were observed in this monkey. Mycobacterium genavense should be considered as a differential for disseminated mycobacterial disease in nonhuman primates as this agent can mimic MAC and related mycobacteria.",

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AU - Bronson, Ellen

AU - Osterhout, Gerard

AU - Parrish, Nicole M.

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Identification of mycobacterium genavense in a diana monkey (cercopithecus diana) by polymerase chain reaction and high-performance liquid chromatography

Abstract

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