Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation

Junqing Guo; Andrew Watson; James Kempson; Marianne Carlsen; Joseph Barbosa; Karen Stebbins; Deborah Lee; John Dodd; Steven G. Nadler; Murray McKinnon; Joel Barrish; William J. Pitts

doi:10.1016/j.bmcl.2009.02.060

Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation

Junqing Guo, Andrew Watson, James Kempson, Marianne Carlsen, Joseph Barbosa, Karen Stebbins, Deborah Lee, John Dodd, Steven G. Nadler, Murray McKinnon, Joel Barrish, William J. Pitts

Chemistry

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A series of pyrimidine based inhibitors of PDE7 are discussed. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members as well as activity in T cells are presented. These compounds were found to have effects on T cell proliferation, however it is not clear whether the mechanism is related to PDE7 inhibition.

Original language	English (US)
Pages (from-to)	1935-1938
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	7
DOIs	https://doi.org/10.1016/j.bmcl.2009.02.060
State	Published - Apr 1 2009

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2009.02.060

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Guo, J., Watson, A., Kempson, J., Carlsen, M., Barbosa, J., Stebbins, K., Lee, D., Dodd, J., Nadler, S. G., McKinnon, M., Barrish, J., & Pitts, W. J. (2009). Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation. Bioorganic and Medicinal Chemistry Letters, 19(7), 1935-1938. https://doi.org/10.1016/j.bmcl.2009.02.060

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author = "Junqing Guo and Andrew Watson and James Kempson and Marianne Carlsen and Joseph Barbosa and Karen Stebbins and Deborah Lee and John Dodd and Nadler, {Steven G.} and Murray McKinnon and Joel Barrish and Pitts, {William J.}",

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Guo, J, Watson, A, Kempson, J, Carlsen, M, Barbosa, J, Stebbins, K, Lee, D, Dodd, J, Nadler, SG, McKinnon, M, Barrish, J & Pitts, WJ 2009, 'Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation', Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 7, pp. 1935-1938. https://doi.org/10.1016/j.bmcl.2009.02.060

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AU - Guo, Junqing

AU - Watson, Andrew

AU - Kempson, James

AU - Carlsen, Marianne

AU - Barbosa, Joseph

AU - Stebbins, Karen

AU - Lee, Deborah

AU - Dodd, John

AU - Nadler, Steven G.

AU - McKinnon, Murray

AU - Barrish, Joel

AU - Pitts, William J.

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Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation

Abstract

All Science Journal Classification (ASJC) codes

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