Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation

Junqing Guo; Andrew Watson; James Kempson; Marianne Carlsen; Joseph Barbosa; Karen Stebbins; Deborah Lee; John Dodd; Steven G. Nadler; Murray McKinnon; Joel Barrish; William J. Pitts

doi:10.1016/j.bmcl.2009.02.060

Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation

Junqing Guo
, Andrew Watson
, James Kempson
, Marianne Carlsen
, Joseph Barbosa
, Karen Stebbins
, Deborah Lee
, John Dodd
, Steven G. Nadler
, Murray McKinnon
, Joel Barrish
, William J. Pitts

Chemistry

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

A series of pyrimidine based inhibitors of PDE7 are discussed. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members as well as activity in T cells are presented. These compounds were found to have effects on T cell proliferation, however it is not clear whether the mechanism is related to PDE7 inhibition.

Original language	English (US)
Pages (from-to)	1935-1938
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	7
DOIs	https://doi.org/10.1016/j.bmcl.2009.02.060
State	Published - Apr 1 2009

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2009.02.060

Cite this

Guo, J., Watson, A., Kempson, J., Carlsen, M., Barbosa, J., Stebbins, K., Lee, D., Dodd, J., Nadler, S. G., McKinnon, M., Barrish, J., & Pitts, W. J. (2009). Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation. Bioorganic and Medicinal Chemistry Letters, 19(7), 1935-1938. https://doi.org/10.1016/j.bmcl.2009.02.060

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abstract = "A series of pyrimidine based inhibitors of PDE7 are discussed. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members as well as activity in T cells are presented. These compounds were found to have effects on T cell proliferation, however it is not clear whether the mechanism is related to PDE7 inhibition.",

author = "Junqing Guo and Andrew Watson and James Kempson and Marianne Carlsen and Joseph Barbosa and Karen Stebbins and Deborah Lee and John Dodd and Nadler, \{Steven G.\} and Murray McKinnon and Joel Barrish and Pitts, \{William J.\}",

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doi = "10.1016/j.bmcl.2009.02.060",

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Guo, J, Watson, A, Kempson, J, Carlsen, M, Barbosa, J, Stebbins, K, Lee, D, Dodd, J, Nadler, SG, McKinnon, M, Barrish, J & Pitts, WJ 2009, 'Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation', Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 7, pp. 1935-1938. https://doi.org/10.1016/j.bmcl.2009.02.060

TY - JOUR

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AU - Guo, Junqing

AU - Watson, Andrew

AU - Kempson, James

AU - Carlsen, Marianne

AU - Barbosa, Joseph

AU - Stebbins, Karen

AU - Lee, Deborah

AU - Dodd, John

AU - Nadler, Steven G.

AU - McKinnon, Murray

AU - Barrish, Joel

AU - Pitts, William J.

PY - 2009/4/1

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AB - A series of pyrimidine based inhibitors of PDE7 are discussed. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members as well as activity in T cells are presented. These compounds were found to have effects on T cell proliferation, however it is not clear whether the mechanism is related to PDE7 inhibition.

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ER -

Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation

Abstract

All Science Journal Classification (ASJC) codes

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