Identification of purine inhibitors of phosphodiesterase 7 (PDE7)

William J. Pitts, Wayne Vaccaro, Tram Huynh, Katerina Leftheris, Jacques Y. Roberge, Joseph Barbosa, Junqing Guo, Baerbel Brown, Andrew Watson, Karen Donaldson, Gary C. Starling, Peter A. Kiener, Michael A. Poss, John H. Dodd, Joel C. Barrish

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


A series of purine based inhibitors of PDE7 has been derived from screening lead 1a. The synthesis, structure-activity relationships (SAR), and selectivity against several other PDE family members are described.

Original languageEnglish (US)
Pages (from-to)2955-2958
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number11
StatePublished - Jun 7 2004

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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