Identification of purine inhibitors of phosphodiesterase 7 (PDE7)

William J. Pitts; Wayne Vaccaro; Tram Huynh; Katerina Leftheris; Jacques Y. Roberge; Joseph Barbosa; Junqing Guo; Baerbel Brown; Andrew Watson; Karen Donaldson; Gary C. Starling; Peter A. Kiener; Michael A. Poss; John H. Dodd; Joel C. Barrish

doi:10.1016/j.bmcl.2004.03.021

Identification of purine inhibitors of phosphodiesterase 7 (PDE7)

William J. Pitts, Wayne Vaccaro, Tram Huynh, Katerina Leftheris, Jacques Y. Roberge, Joseph Barbosa, Junqing Guo, Baerbel Brown, Andrew Watson, Karen Donaldson, Gary C. Starling, Peter A. Kiener, Michael A. Poss, John H. Dodd, Joel C. Barrish

Chemistry

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

A series of purine based inhibitors of PDE7 has been derived from screening lead 1a. The synthesis, structure-activity relationships (SAR), and selectivity against several other PDE family members are described.

Original language	English (US)
Pages (from-to)	2955-2958
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	11
DOIs	https://doi.org/10.1016/j.bmcl.2004.03.021
State	Published - Jun 7 2004

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2004.03.021

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Pitts, W. J., Vaccaro, W., Huynh, T., Leftheris, K., Roberge, J. Y., Barbosa, J., Guo, J., Brown, B., Watson, A., Donaldson, K., Starling, G. C., Kiener, P. A., Poss, M. A., Dodd, J. H., & Barrish, J. C. (2004). Identification of purine inhibitors of phosphodiesterase 7 (PDE7). Bioorganic and Medicinal Chemistry Letters, 14(11), 2955-2958. https://doi.org/10.1016/j.bmcl.2004.03.021

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author = "Pitts, {William J.} and Wayne Vaccaro and Tram Huynh and Katerina Leftheris and Roberge, {Jacques Y.} and Joseph Barbosa and Junqing Guo and Baerbel Brown and Andrew Watson and Karen Donaldson and Starling, {Gary C.} and Kiener, {Peter A.} and Poss, {Michael A.} and Dodd, {John H.} and Barrish, {Joel C.}",

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AU - Pitts, William J.

AU - Vaccaro, Wayne

AU - Huynh, Tram

AU - Leftheris, Katerina

AU - Roberge, Jacques Y.

AU - Barbosa, Joseph

AU - Guo, Junqing

AU - Brown, Baerbel

AU - Watson, Andrew

AU - Donaldson, Karen

AU - Starling, Gary C.

AU - Kiener, Peter A.

AU - Poss, Michael A.

AU - Dodd, John H.

AU - Barrish, Joel C.

PY - 2004/6/7

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 11

ER -

Identification of purine inhibitors of phosphodiesterase 7 (PDE7)

Abstract

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