IGEMS: The consortium on interplay of genes and environment across multiple studies

Nancy L. Pedersen, Kaare Christensen, Anna K. Dahl, Deborah Finkel, Carol E. Franz, Margaret Gatz, Briana N. Horwitz, Boo Johansson, Wendy Johnson, William S. Kremen, Michael J. Lyons, Bo Malmberg, Matt McGue, Jenae M. Neiderhiser, Inge Petersen, Chandra A. Reynolds

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


The Interplay of Genes and Environment across Multiple Studies (IGEMS) group is a consortium of eight longitudinal twin studies established to explore the nature of social context effects and gene-environment interplay in late-life functioning. The resulting analysis of the combined data from over 17,500 participants aged 25-102 at baseline (including nearly 2,600 monogygotic and 4,300 dizygotic twin pairs and over 1,700 family members) aims to understand why early life adversity, and social factors such as isolation and loneliness, are associated with diverse outcomes including mortality, physical functioning (health, functional ability), and psychological functioning (well-being, cognition), particularly in later life.

Original languageEnglish (US)
Pages (from-to)481-489
Number of pages9
JournalTwin Research and Human Genetics
Issue number1
StatePublished - Feb 2013

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology
  • Genetics(clinical)


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