IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update

Nancy L. Pedersen; Margaret Gatz; Brian K. Finch; Deborah Finkel; David A. Butler; Anna Dahl Aslan; Carol E. Franz; Jaakko Kaprio; Susan Lapham; Matt McGue; Miriam A. Mosing; Jenae Neiderhiser; Marianne Nygaard; Matthew Panizzon; Carol A. Prescott; Chandra A. Reynolds; Perminder Sachdev; Keith E. Whitfield

doi:10.1017/thg.2019.76

IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update

Nancy L. Pedersen, Margaret Gatz, Brian K. Finch, Deborah Finkel, David A. Butler, Anna Dahl Aslan, Carol E. Franz, Jaakko Kaprio, Susan Lapham, Matt McGue, Miriam A. Mosing, Jenae Neiderhiser, Marianne Nygaard, Matthew Panizzon, Carol A. Prescott, Chandra A. Reynolds, Perminder Sachdev, Keith E. Whitfield

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20 Scopus citations

Abstract

The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 18 twin studies from 5 different countries (Sweden, Denmark, Finland, United States, and Australia) established to explore the nature of gene-environment (GE) interplay in functioning across the adult lifespan. Fifteen of the studies are longitudinal, with follow-up as long as 59 years after baseline. The combined data from over 76,000 participants aged 14-103 at intake (including over 10,000 monozygotic and over 17,000 dizygotic twin pairs) support two primary research emphases: (1) investigation of models of GE interplay of early life adversity, and social factors at micro and macro environmental levels and with diverse outcomes, including mortality, physical functioning and psychological functioning; and (2) improved understanding of risk and protective factors for dementia by incorporating unmeasured and measured genetic factors with a wide range of exposures measured in young adulthood, midlife and later life.

Original language	English (US)
Pages (from-to)	809-816
Number of pages	8
Journal	Twin Research and Human Genetics
Volume	22
Issue number	6
DOIs	https://doi.org/10.1017/thg.2019.76
State	Published - Dec 1 2019

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology
Genetics(clinical)

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10.1017/thg.2019.76

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Pedersen, N. L., Gatz, M., Finch, B. K., Finkel, D., Butler, D. A., Dahl Aslan, A., Franz, C. E., Kaprio, J., Lapham, S., McGue, M., Mosing, M. A., Neiderhiser, J., Nygaard, M., Panizzon, M., Prescott, C. A., Reynolds, C. A., Sachdev, P., & Whitfield, K. E. (2019). IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update. Twin Research and Human Genetics, 22(6), 809-816. https://doi.org/10.1017/thg.2019.76

@article{545d99555635468ab166492848aafc8c,

title = "IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update",

abstract = "The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 18 twin studies from 5 different countries (Sweden, Denmark, Finland, United States, and Australia) established to explore the nature of gene-environment (GE) interplay in functioning across the adult lifespan. Fifteen of the studies are longitudinal, with follow-up as long as 59 years after baseline. The combined data from over 76,000 participants aged 14-103 at intake (including over 10,000 monozygotic and over 17,000 dizygotic twin pairs) support two primary research emphases: (1) investigation of models of GE interplay of early life adversity, and social factors at micro and macro environmental levels and with diverse outcomes, including mortality, physical functioning and psychological functioning; and (2) improved understanding of risk and protective factors for dementia by incorporating unmeasured and measured genetic factors with a wide range of exposures measured in young adulthood, midlife and later life.",

author = "Pedersen, \{Nancy L.\} and Margaret Gatz and Finch, \{Brian K.\} and Deborah Finkel and Butler, \{David A.\} and \{Dahl Aslan\}, Anna and Franz, \{Carol E.\} and Jaakko Kaprio and Susan Lapham and Matt McGue and Mosing, \{Miriam A.\} and Jenae Neiderhiser and Marianne Nygaard and Matthew Panizzon and Prescott, \{Carol A.\} and Reynolds, \{Chandra A.\} and Perminder Sachdev and Whitfield, \{Keith E.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2019.",

year = "2019",

month = dec,

day = "1",

doi = "10.1017/thg.2019.76",

language = "English (US)",

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Pedersen, NL, Gatz, M, Finch, BK, Finkel, D, Butler, DA, Dahl Aslan, A, Franz, CE, Kaprio, J, Lapham, S, McGue, M, Mosing, MA, Neiderhiser, J, Nygaard, M, Panizzon, M, Prescott, CA, Reynolds, CA, Sachdev, P & Whitfield, KE 2019, 'IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update', Twin Research and Human Genetics, vol. 22, no. 6, pp. 809-816. https://doi.org/10.1017/thg.2019.76

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AU - Pedersen, Nancy L.

AU - Gatz, Margaret

AU - Finch, Brian K.

AU - Finkel, Deborah

AU - Butler, David A.

AU - Dahl Aslan, Anna

AU - Franz, Carol E.

AU - Kaprio, Jaakko

AU - Lapham, Susan

AU - McGue, Matt

AU - Mosing, Miriam A.

AU - Neiderhiser, Jenae

AU - Nygaard, Marianne

AU - Panizzon, Matthew

AU - Prescott, Carol A.

AU - Reynolds, Chandra A.

AU - Sachdev, Perminder

AU - Whitfield, Keith E.

PY - 2019/12/1

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IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update

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