IgSimulator: A versatile immunosequencing simulator

Yana Safonova, Alla Lapidus, Jennie Lill

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Motivation: The recent introduction of next-generation sequencing technologies to antibody studies have resulted in a growing number of immunoinformatics tools for antibody repertoire analysis. However, benchmarking these newly emerging tools remains problematic since the gold standard datasets that are needed to validate these tools are typically not available. Results: Since simulating antibody repertoires is often the only feasible way to benchmark new immunoinformatics tools, we developed the IgSimulator tool that addresses various complications in generating realistic antibody repertoires. IgSimulator's code has modular structure and can be easily adapted to new requirements to simulation.

Original languageEnglish (US)
Pages (from-to)3213-3215
Number of pages3
JournalBioinformatics
Volume31
Issue number19
DOIs
StatePublished - Oct 1 2015

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

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