IL-2-inducible T-cell kinase (ITK) finds another (dance) partnery...TFII-I

Avery August

Research output: Contribution to journalComment/debatepeer-review

4 Scopus citations


The signals that regulate T-cell activation have been studied for some time. We know that upon interaction with antigen/MHC complex, the TCR triggers the activation of a number of kinases, including tyrosine and serine/threonine kinases. The Tec family kinase IL-2-inducible T-cell kinase (ITK) plays a role in this response, but the signaling pathways that ITK regulates are less well known. Even less known are the binding partners and substrates of ITK. A paper in this issue of the European Journal of Immunology extends our knowledge on the subject by showing that ITK interacts with the transcriptional regulator TFII-I. The implications of this finding are discussed.

Original languageEnglish (US)
Pages (from-to)2354-2357
Number of pages4
JournalEuropean Journal of Immunology
Issue number9
StatePublished - Sep 2009

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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