Abstract
The signals that regulate T-cell activation have been studied for some time. We know that upon interaction with antigen/MHC complex, the TCR triggers the activation of a number of kinases, including tyrosine and serine/threonine kinases. The Tec family kinase IL-2-inducible T-cell kinase (ITK) plays a role in this response, but the signaling pathways that ITK regulates are less well known. Even less known are the binding partners and substrates of ITK. A paper in this issue of the European Journal of Immunology extends our knowledge on the subject by showing that ITK interacts with the transcriptional regulator TFII-I. The implications of this finding are discussed.
Original language | English (US) |
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Pages (from-to) | 2354-2357 |
Number of pages | 4 |
Journal | European Journal of Immunology |
Volume | 39 |
Issue number | 9 |
DOIs |
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State | Published - Sep 2009 |
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology