Iliski, a software for robust calculation of transfer functions

Ali Kemal Aydin, William D. Haselden, Julie Dang, Patrick J. Drew, Serge Charpak, Davide Boido

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Understanding the relationships between biological processes is paramount to unravel pathophysiological mechanisms. These relationships can be modeled with Transfer Functions (TFs), with no need of a priori hypotheses as to the shape of the transfer function. Here we present Iliski, a software dedicated to TFs computation between two signals. It includes different pre-treatment routines and TF computation processes: deconvolution, deterministic and non-deterministic optimization algorithms that are adapted to disparate datasets. We apply Iliski to data on neurovascular coupling, an ensemble of cellular mechanisms that link neuronal activity to local changes of blood flow, highlighting the software benefits and caveats in the computation and evaluation of TFs. We also propose a workflow that will help users to choose the best computation according to the dataset. Iliski is available under the open-source license CC BY 4.0 on GitHub ( and can be used on the most common operating systems, either within the MATLAB environment, or as a standalone application.

Original languageEnglish (US)
Article numbere1008614
JournalPLoS computational biology
Issue number6
StatePublished - Jun 2021

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Modeling and Simulation
  • Ecology
  • Molecular Biology
  • Genetics
  • Cellular and Molecular Neuroscience
  • Computational Theory and Mathematics


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