TY - GEN
T1 - Image-based detection of corpus callosum variability for more accurate discrimination between autistic and normal brains
AU - Elnakib, Ahmed
AU - El-Baz, Ayman
AU - Casanova, Manuel F.
AU - Gimel'farb, Georgy
AU - Switala, Andrew E.
PY - 2010
Y1 - 2010
N2 - The importance of accurate early diagnostics of autism that severely affects personal behavior and communication skills cannot be overstated. Neuropathological studies have revealed an abnormal anatomy of the Corpus Callosum (CC) in autistic brains. We propose a new approach to quantitative analysis of three-dimensional (3D) magnetic resonance images (MRI) of the brain that ensures a more accurate quantification of anatomical differences between the CC of autistic and normal subjects. It consists of three main processing steps: (i) segmenting the CC from a given 3D MRI using the learned CC shape and visual appearance; (ii) extracting a centerline of the CC; and (iii) cylindrical mapping of the CC surface for its comparative analysis. Our experiments revealed significant differences (at the 95% confidence level) between 17 normal and 17 autistic subjects in four anatomical divisions, i.e. splenium, rostrum, genu and body of their CC.
AB - The importance of accurate early diagnostics of autism that severely affects personal behavior and communication skills cannot be overstated. Neuropathological studies have revealed an abnormal anatomy of the Corpus Callosum (CC) in autistic brains. We propose a new approach to quantitative analysis of three-dimensional (3D) magnetic resonance images (MRI) of the brain that ensures a more accurate quantification of anatomical differences between the CC of autistic and normal subjects. It consists of three main processing steps: (i) segmenting the CC from a given 3D MRI using the learned CC shape and visual appearance; (ii) extracting a centerline of the CC; and (iii) cylindrical mapping of the CC surface for its comparative analysis. Our experiments revealed significant differences (at the 95% confidence level) between 17 normal and 17 autistic subjects in four anatomical divisions, i.e. splenium, rostrum, genu and body of their CC.
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U2 - 10.1109/ICIP.2010.5652409
DO - 10.1109/ICIP.2010.5652409
M3 - Conference contribution
AN - SCOPUS:78651065981
SN - 9781424479948
T3 - Proceedings - International Conference on Image Processing, ICIP
SP - 4337
EP - 4340
BT - 2010 IEEE International Conference on Image Processing, ICIP 2010 - Proceedings
T2 - 2010 17th IEEE International Conference on Image Processing, ICIP 2010
Y2 - 26 September 2010 through 29 September 2010
ER -