TY - GEN
T1 - Image-based detection of Corpus Callosum variability for more accurate discrimination between dyslexic and normal brains
AU - Elnakib, Ahmed
AU - El-Baz, Ayman
AU - Casanova, Manuel F.
AU - Gimel'Farb, Georgy
AU - Switala, Andrew E.
PY - 2010
Y1 - 2010
N2 - Dyslexia severely impairs learning abilities of children, so that improved diagnostic methods are needed. Neuropathological studies have revealed an abnormal anatomy of the Corpus Callosum (CC) in dyslexic brains. We propose a new approach to quantitative analysis of three-dimensional (3D) magnetic resonance images (MRI) of the brain that ensures a more accurate quantification of anatomical differences between the CC of dyslexic and normal subjects. It consists of three main processing steps: (i) segmenting the CC from a given 3D MRI using the learned CC shape and visual appearance; (ii) extracting a centerline of the CC; and (iii) cylindrical mapping of the CC surface for its comparative analysis. Our experiments revealed significant differences (at the 95% confidence level) between 14 normal and 16 dyslexic subjects in four anatomical divisions, i.e. splenium, rostrum, genu and body of their CCs.
AB - Dyslexia severely impairs learning abilities of children, so that improved diagnostic methods are needed. Neuropathological studies have revealed an abnormal anatomy of the Corpus Callosum (CC) in dyslexic brains. We propose a new approach to quantitative analysis of three-dimensional (3D) magnetic resonance images (MRI) of the brain that ensures a more accurate quantification of anatomical differences between the CC of dyslexic and normal subjects. It consists of three main processing steps: (i) segmenting the CC from a given 3D MRI using the learned CC shape and visual appearance; (ii) extracting a centerline of the CC; and (iii) cylindrical mapping of the CC surface for its comparative analysis. Our experiments revealed significant differences (at the 95% confidence level) between 14 normal and 16 dyslexic subjects in four anatomical divisions, i.e. splenium, rostrum, genu and body of their CCs.
UR - http://www.scopus.com/inward/record.url?scp=77955179106&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955179106&partnerID=8YFLogxK
U2 - 10.1109/ISBI.2010.5490403
DO - 10.1109/ISBI.2010.5490403
M3 - Conference contribution
AN - SCOPUS:77955179106
SN - 9781424441266
T3 - 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings
SP - 109
EP - 112
BT - 2010 7th IEEE International Symposium on Biomedical Imaging
T2 - 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010
Y2 - 14 April 2010 through 17 April 2010
ER -