Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking

Susumu Mori; Walter E. Kaufmann; Christos Davatzikos; Bram Stieltjes; Laura Amodei; Kim Fredericksen; Godfrey D. Pearlson; Elias R. Melhem; Meiyappan Solaiyappan; Gerald V. Raymond; Hugo W. Moser; Peter C.M. Van Zijl

doi:10.1002/mrm.10074

Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking

Susumu Mori, Walter E. Kaufmann, Christos Davatzikos, Bram Stieltjes, Laura Amodei, Kim Fredericksen, Godfrey D. Pearlson, Elias R. Melhem, Meiyappan Solaiyappan, Gerald V. Raymond, Hugo W. Moser, Peter C.M. Van Zijl

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

478 Scopus citations

Abstract

Diffusion-tensor fiber tracking was used to identify the cores of several long-association fibers, including the anterior (ATR) and posterior (PTR) thalamic radiations, and the uncinate (UNC), superior longitudinal (SLF), inferior longitudinal (ILF), and inferior fronto-occipital (IFO) fasciculi. Tracking results were compared to existing anatomical knowledge, and showed good qualitative agreement. Guidelines were developed to reproducibly track these fibers in vivo. The interindividual variability of these reconstructions was assessed in a common spatial reference frame (Talairach space) using probabilistic mapping. As a first illustration of this technical capability, a reduction in brain connectivity in a patient with a childhood neurodegenerative disease (X-linked adrenoleukodystrophy) was demonstrated.

Original language	English (US)
Pages (from-to)	215-223
Number of pages	9
Journal	Magnetic Resonance in Medicine
Volume	47
Issue number	2
DOIs	https://doi.org/10.1002/mrm.10074
State	Published - 2002

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging

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10.1002/mrm.10074

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Mori, S., Kaufmann, W. E., Davatzikos, C., Stieltjes, B., Amodei, L., Fredericksen, K., Pearlson, G. D., Melhem, E. R., Solaiyappan, M., Raymond, G. V., Moser, H. W., & Van Zijl, P. C. M. (2002). Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking. Magnetic Resonance in Medicine, 47(2), 215-223. https://doi.org/10.1002/mrm.10074

@article{249d802c4ffe45bf8c630dd33d477e5d,

title = "Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking",

abstract = "Diffusion-tensor fiber tracking was used to identify the cores of several long-association fibers, including the anterior (ATR) and posterior (PTR) thalamic radiations, and the uncinate (UNC), superior longitudinal (SLF), inferior longitudinal (ILF), and inferior fronto-occipital (IFO) fasciculi. Tracking results were compared to existing anatomical knowledge, and showed good qualitative agreement. Guidelines were developed to reproducibly track these fibers in vivo. The interindividual variability of these reconstructions was assessed in a common spatial reference frame (Talairach space) using probabilistic mapping. As a first illustration of this technical capability, a reduction in brain connectivity in a patient with a childhood neurodegenerative disease (X-linked adrenoleukodystrophy) was demonstrated.",

author = "Susumu Mori and Kaufmann, {Walter E.} and Christos Davatzikos and Bram Stieltjes and Laura Amodei and Kim Fredericksen and Pearlson, {Godfrey D.} and Melhem, {Elias R.} and Meiyappan Solaiyappan and Raymond, {Gerald V.} and Moser, {Hugo W.} and {Van Zijl}, {Peter C.M.}",

year = "2002",

doi = "10.1002/mrm.10074",

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AU - Mori, Susumu

AU - Kaufmann, Walter E.

AU - Davatzikos, Christos

AU - Stieltjes, Bram

AU - Amodei, Laura

AU - Fredericksen, Kim

AU - Pearlson, Godfrey D.

AU - Melhem, Elias R.

AU - Solaiyappan, Meiyappan

AU - Raymond, Gerald V.

AU - Moser, Hugo W.

AU - Van Zijl, Peter C.M.

PY - 2002

Y1 - 2002

N2 - Diffusion-tensor fiber tracking was used to identify the cores of several long-association fibers, including the anterior (ATR) and posterior (PTR) thalamic radiations, and the uncinate (UNC), superior longitudinal (SLF), inferior longitudinal (ILF), and inferior fronto-occipital (IFO) fasciculi. Tracking results were compared to existing anatomical knowledge, and showed good qualitative agreement. Guidelines were developed to reproducibly track these fibers in vivo. The interindividual variability of these reconstructions was assessed in a common spatial reference frame (Talairach space) using probabilistic mapping. As a first illustration of this technical capability, a reduction in brain connectivity in a patient with a childhood neurodegenerative disease (X-linked adrenoleukodystrophy) was demonstrated.

AB - Diffusion-tensor fiber tracking was used to identify the cores of several long-association fibers, including the anterior (ATR) and posterior (PTR) thalamic radiations, and the uncinate (UNC), superior longitudinal (SLF), inferior longitudinal (ILF), and inferior fronto-occipital (IFO) fasciculi. Tracking results were compared to existing anatomical knowledge, and showed good qualitative agreement. Guidelines were developed to reproducibly track these fibers in vivo. The interindividual variability of these reconstructions was assessed in a common spatial reference frame (Talairach space) using probabilistic mapping. As a first illustration of this technical capability, a reduction in brain connectivity in a patient with a childhood neurodegenerative disease (X-linked adrenoleukodystrophy) was demonstrated.

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JO - Magnetic Resonance in Medicine

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Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking

Abstract

All Science Journal Classification (ASJC) codes

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