Imaging of optical scattering contrast using ultrasound-modulated optical tomography

Sri Rajasekhar Kothapalli, Sava Sakadžić, Chulhong Kim, Lihong V. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


Using a CCD-based speckle contrast detection scheme of ultrasound-modulated optical tomography (UOT), we show the feasibility of imaging objects having different optical scattering coefficients relative to the surrounding scattering medium. Our results show that the spatial resolution depends on the ultrasound parameters and the image contrast depends on the difference in scattering coefficient between the object and the surrounding medium. Experimental measurements are in agreement with Monte Carlo simulations and analytical calculations. This study complements previous UOT experiments that demonstrated optical absorption contrast. It also demonstrates that UOT complements photoacoustic tomography, which is sensitive to optical absorption contrast.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
ISBN (Print)9780819470317
StatePublished - Mar 11 2008
Event9th Conference on Photons Plus Ultrasound: Imaging and Sensing 2008 - San Jose, CA, United States
Duration: Jan 20 2008Jan 23 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


Other9th Conference on Photons Plus Ultrasound: Imaging and Sensing 2008
Country/TerritoryUnited States
CitySan Jose, CA

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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