TY - JOUR
T1 - Immune changes in test animals during spaceflight
AU - Lesnyak, A. T.
AU - Sonnenfeld, G.
AU - Rykova, M. P.
AU - Meshkov, D. O.
AU - Mastro, A.
AU - Konstantinova, I.
PY - 1993
Y1 - 1993
N2 - Over the past two decades, it has become apparent that changes in immune parameters occur in cosmonauts and astronauts after spaceflight. Therefore, interest has been generated in the use of animal surrogates to better understand the nature and extent of these changes, the mechanism of these changes, and to allow the possible development of countermeasures. Among the changes noted in animals after spaceflight are alterations in lymphocytic blastogenesis, cytokine function, natural killer cell activity, and colony- stimulating factors. The nature and significance of spaceflight-induced changes in immune responses will be the focus of this review.
AB - Over the past two decades, it has become apparent that changes in immune parameters occur in cosmonauts and astronauts after spaceflight. Therefore, interest has been generated in the use of animal surrogates to better understand the nature and extent of these changes, the mechanism of these changes, and to allow the possible development of countermeasures. Among the changes noted in animals after spaceflight are alterations in lymphocytic blastogenesis, cytokine function, natural killer cell activity, and colony- stimulating factors. The nature and significance of spaceflight-induced changes in immune responses will be the focus of this review.
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U2 - 10.1002/jlb.54.3.214
DO - 10.1002/jlb.54.3.214
M3 - Article
C2 - 8371051
AN - SCOPUS:0027454148
SN - 0741-5400
VL - 54
SP - 214
EP - 226
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
IS - 3
ER -