Immune changes in test animals during spaceflight

A. T. Lesnyak, G. Sonnenfeld, M. P. Rykova, D. O. Meshkov, A. Mastro, I. Konstantinova

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Over the past two decades, it has become apparent that changes in immune parameters occur in cosmonauts and astronauts after spaceflight. Therefore, interest has been generated in the use of animal surrogates to better understand the nature and extent of these changes, the mechanism of these changes, and to allow the possible development of countermeasures. Among the changes noted in animals after spaceflight are alterations in lymphocytic blastogenesis, cytokine function, natural killer cell activity, and colony- stimulating factors. The nature and significance of spaceflight-induced changes in immune responses will be the focus of this review.

Original languageEnglish (US)
Pages (from-to)214-226
Number of pages13
JournalJournal of Leukocyte Biology
Issue number3
StatePublished - 1993

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Cell Biology


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