TY - JOUR
T1 - Immune mediated necrotizing myopathy
T2 - A rare complication of statin therapy
AU - Abusharar, Shady Piedra
AU - Moku, Prashanth
AU - Banks, Sharon
AU - Khalid, Fahad M.
AU - Specht, Charles S.
AU - Polimera, Hyma V.
N1 - Publisher Copyright:
© the Author(s), 2020.
PY - 2020
Y1 - 2020
N2 - Immune mediated necrotizing myopathy (IMNM) is part of the inflammatory myopathies group of diseases and presents with muscle weakness, myalgias and elevated serum creatine phosphokinase (CPK). Statin-induced IMNM is a rare complication. We present a patient with IMNM secondary to simvastatin use. The patient presented with proximal myopathy, dysphagia, and elevated creatinine kinase levels, and was subsequently found to have anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) autoantibodies with a necrotiz-ing process on muscle biopsy. This patient’s case was further complicated by sequelae of multiple disease processes, ultimately lead-ing to deterioration of his health.
AB - Immune mediated necrotizing myopathy (IMNM) is part of the inflammatory myopathies group of diseases and presents with muscle weakness, myalgias and elevated serum creatine phosphokinase (CPK). Statin-induced IMNM is a rare complication. We present a patient with IMNM secondary to simvastatin use. The patient presented with proximal myopathy, dysphagia, and elevated creatinine kinase levels, and was subsequently found to have anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) autoantibodies with a necrotiz-ing process on muscle biopsy. This patient’s case was further complicated by sequelae of multiple disease processes, ultimately lead-ing to deterioration of his health.
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U2 - 10.4081/cp.2020.1248
DO - 10.4081/cp.2020.1248
M3 - Article
AN - SCOPUS:85136104346
SN - 2039-7283
VL - 10
SP - 1
EP - 4
JO - Clinics and Practice
JF - Clinics and Practice
IS - 2
M1 - 1248
ER -