TY - JOUR
T1 - Immune thrombocytopenia after umbilical cord progenitor cell transplant
T2 - Response to vincristine
AU - Dovat, S.
AU - Roberts, R. L.
AU - Wakim, M.
AU - Stiehm, E. R.
AU - Feig, S. A.
N1 - Funding Information:
This work was supported in part by Pediatric AIDS Foundation grants 77186, 500327 and 50463 (RLR and ERS). SD is the recipient of the Norman Fellowship of the National Childhood Cancer Foundation.
PY - 1999
Y1 - 1999
N2 - An 8-month-old male with X-linked lymphoproliferative disease underwent an unrelated, partially matched (with major mismatch at DR locus), cord blood stem cell transplant. Four months following the transplant, he developed immune thrombocytopenia with hemolytic anemia (Evans syndrome). He received multiple courses of intravenous immunoglobulin, anti-Rh D immunoglobulin, a pulse of high-dose corticosteroids and cyclosporine with some improvement of hemolytic anemia, but no improvement of the thrombocytopenia. Addition of vincristine, resulted in long-term resolution of thrombocytopenia and anemia. No major toxicity was observed during treatment. Vincristine should be considered as a treatment for refractory immune thrombocytopenia after hematopoietic stem cell transplantation.
AB - An 8-month-old male with X-linked lymphoproliferative disease underwent an unrelated, partially matched (with major mismatch at DR locus), cord blood stem cell transplant. Four months following the transplant, he developed immune thrombocytopenia with hemolytic anemia (Evans syndrome). He received multiple courses of intravenous immunoglobulin, anti-Rh D immunoglobulin, a pulse of high-dose corticosteroids and cyclosporine with some improvement of hemolytic anemia, but no improvement of the thrombocytopenia. Addition of vincristine, resulted in long-term resolution of thrombocytopenia and anemia. No major toxicity was observed during treatment. Vincristine should be considered as a treatment for refractory immune thrombocytopenia after hematopoietic stem cell transplantation.
UR - https://www.scopus.com/pages/publications/0032784658
UR - https://www.scopus.com/inward/citedby.url?scp=0032784658&partnerID=8YFLogxK
U2 - 10.1038/sj.bmt.1701888
DO - 10.1038/sj.bmt.1701888
M3 - Article
C2 - 10455373
AN - SCOPUS:0032784658
SN - 0268-3369
VL - 24
SP - 321
EP - 323
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
IS - 3
ER -