TY - JOUR
T1 - Immunity to polyomavirus infection
T2 - The polyomavirus-mouse model
AU - Swanson, Phillip A.
AU - Lukacher, Aron E.
AU - Szomolanyi-Tsuda, Eva
N1 - Funding Information:
Work described in this review was supported by National Cancer Institute grants R01CA71971, R01CA100644 (A.E. Lukacher) and R01CA66644 (E. Szomolanyi-Tsuda).
PY - 2009/8
Y1 - 2009/8
N2 - A ubiquitous clinically silent murine pathogen, polyomavirus has enjoyed long-term co-evolution with the mouse, a highly tractable and genetically and immunologically informative small animal model. Thus, polyomavirus has provided a valuable experimental construct to decipher the host immune mechanisms that come into play to control systemic low-level persistent viral infections. Impaired immunosurveillance for infected cells puts the murine host at risk both to injury resulting from excessive direct virus cytolysis and development of virus-induced tumors. In this review, we present our current understanding of the multifaceted immune response invoked by the mouse to maintain détente with this potentially deleterious persistent natural pathogen, and discuss implications of these studies for therapeutic interventions for human polyomavirus infection.
AB - A ubiquitous clinically silent murine pathogen, polyomavirus has enjoyed long-term co-evolution with the mouse, a highly tractable and genetically and immunologically informative small animal model. Thus, polyomavirus has provided a valuable experimental construct to decipher the host immune mechanisms that come into play to control systemic low-level persistent viral infections. Impaired immunosurveillance for infected cells puts the murine host at risk both to injury resulting from excessive direct virus cytolysis and development of virus-induced tumors. In this review, we present our current understanding of the multifaceted immune response invoked by the mouse to maintain détente with this potentially deleterious persistent natural pathogen, and discuss implications of these studies for therapeutic interventions for human polyomavirus infection.
UR - http://www.scopus.com/inward/record.url?scp=67349165834&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349165834&partnerID=8YFLogxK
U2 - 10.1016/j.semcancer.2009.02.003
DO - 10.1016/j.semcancer.2009.02.003
M3 - Review article
C2 - 19505652
AN - SCOPUS:67349165834
SN - 1044-579X
VL - 19
SP - 244
EP - 251
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
IS - 4
ER -
