TY - JOUR
T1 - Immunoglobulin G and Its Function in the Human Respiratory Tract
AU - REYNOLDS, HERBERT Y.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1988
Y1 - 1988
N2 - Immunoglobulin G—which can be subdivided into four classes, each with different functional characteristics—is an important component of the host defense system of the respiratory tract. An excessive amount can be produced or can accumulate after airway irritation (exposure to cigarette smoke) or from immunologic stimulus of B-lymphocyte-plasma cells in types of hypersensitivity and interstitial lung diseases. Specific antibody activity can be identified in organic dust-induced hypersensitivity pneumonitis and asthma that contributes to disease pathogenesis. The availability of opsonic antimicrobial antibodies is essential for optimal function of phagocytes in uptake and containment of bacteria. With an absolute or functional deficiency of IgG, recurrent and chronic types of sinopulmonary infections occur. These extremes of IgG availability, either high levels (presumably excessive) or deficient, are discussed in this review.
AB - Immunoglobulin G—which can be subdivided into four classes, each with different functional characteristics—is an important component of the host defense system of the respiratory tract. An excessive amount can be produced or can accumulate after airway irritation (exposure to cigarette smoke) or from immunologic stimulus of B-lymphocyte-plasma cells in types of hypersensitivity and interstitial lung diseases. Specific antibody activity can be identified in organic dust-induced hypersensitivity pneumonitis and asthma that contributes to disease pathogenesis. The availability of opsonic antimicrobial antibodies is essential for optimal function of phagocytes in uptake and containment of bacteria. With an absolute or functional deficiency of IgG, recurrent and chronic types of sinopulmonary infections occur. These extremes of IgG availability, either high levels (presumably excessive) or deficient, are discussed in this review.
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U2 - 10.1016/S0025-6196(12)64949-0
DO - 10.1016/S0025-6196(12)64949-0
M3 - Review article
C2 - 3276975
AN - SCOPUS:0023863150
SN - 0025-6196
VL - 63
SP - 161
EP - 174
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
IS - 2
ER -