TY - JOUR
T1 - Immunoglobulin G Immunosuppression of Multiple Sclerosis
T2 - Suppression of All Three Major Lymphocyte Subsets
AU - Tenser, Richard B.
AU - Hay, Kathleen A.
AU - Aberg, Judith A.
PY - 1993/4
Y1 - 1993/4
N2 - Six patients with relapsing chronic progressive multiple sclerosis were treated on 2 consecutive days with large amounts of IgG to induce immunosuppression. Peripheral blood lymphocyte subsets were monitored for 5 weeks after IgG treatment to determine immunosuppression. Decreased numbers of B, T, and natural killer lymphocytes were detected after treatment. Lymphocyte numbers were at a nadir 1 week after treatment, but an immunosuppressive effect continued to be present after 5 weeks. Although clinical efficacy was not evident in this brief open trial, the decrease of peripheral lymphocyte numbers and the apparent safety of the procedure warrant further study.
AB - Six patients with relapsing chronic progressive multiple sclerosis were treated on 2 consecutive days with large amounts of IgG to induce immunosuppression. Peripheral blood lymphocyte subsets were monitored for 5 weeks after IgG treatment to determine immunosuppression. Decreased numbers of B, T, and natural killer lymphocytes were detected after treatment. Lymphocyte numbers were at a nadir 1 week after treatment, but an immunosuppressive effect continued to be present after 5 weeks. Although clinical efficacy was not evident in this brief open trial, the decrease of peripheral lymphocyte numbers and the apparent safety of the procedure warrant further study.
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U2 - 10.1001/archneur.1993.00540040069017
DO - 10.1001/archneur.1993.00540040069017
M3 - Article
C2 - 8460964
AN - SCOPUS:0027409418
SN - 0003-9942
VL - 50
SP - 417
EP - 420
JO - Archives of Neurology
JF - Archives of Neurology
IS - 4
ER -