Immunohistochemical acid phosphatase level and tumor grade in prostatic carcinoma

M. S. Bentz, C. Cohen, L. M. Demers, L. R. Budgeon

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


An immunoperoxidase technique to detect prostatic-specific acid phosphatase (PSAP) was used on specimens from 98 cases of prostatic carcinoma that were graded by both the Gleason and the Mostofi systems, to see if tumor grade correlated wtih amount of PSAP seen in tissue. Most tumors showed strong, diffuse cytoplasmic staining; no significant difference was seen among the various grades. Other than focal, weak staining of renal tubular epithelium, the antibody to PSAP gave uniformly negative results with a variety of normal and neoplastic tissues. In light of the great sensitivity and specificity of this technique, its potential applications include diagnosis of poorly differentiated prostatic malignant neoplasms, whether primary or metastatic.

Original languageEnglish (US)
Pages (from-to)476-480
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Issue number9
StatePublished - Jan 1 1982

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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