Immunology of acne

Galen T. Foulke; Amanda M. Nelson

doi:10.1007/978-3-319-29785-9_24

Immunology of acne

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Activation of the immune system is a central event in the development of acne, and our understanding of this process is rapidly expanding. In this chapter, we describe how P. acnes, sebaceous glands, and keratinocytes contribute to inflammation in acne and how current acne treatments modulate this immune response. Specifically, we address the role of anti-microbial peptides, Toll-Like Receptors (TLRs), sebaceous lipids as well as cytokines and the role of the inflammasome as driving inflammation in acne. The anti-inflammatory activities of retinoids, tetracyclines and other therapies are discussed.

Original language	English (US)
Title of host publication	Clinical and Basic Immunodermatology
Subtitle of host publication	Second Edition
Publisher	Springer International Publishing
Pages	431-438
Number of pages	8
ISBN (Electronic)	9783319297859
ISBN (Print)	9783319297835
DOIs	https://doi.org/10.1007/978-3-319-29785-9_24
State	Published - Apr 24 2017

All Science Journal Classification (ASJC) codes

General Medicine
General Immunology and Microbiology

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10.1007/978-3-319-29785-9_24

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Immunology of acne

Abstract

All Science Journal Classification (ASJC) codes

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