Immunomodulator immunomax activates dendritic cells

Earlier it was reported that immunomodulator Immunomax activates monocytes, macrophages and NK cells. In this work, we first studied the effect of Immunomax on dendritic cells of mouse and human. Researched primary dendritic cells isolated by cell sorting from mouse spleen or human peripheral blood, as well as artificially derived dendritic cells differentiated in vitro with GM-CSF from bone marrow of the mouse or human monocytes. It is established that the Immunomax increases the expression of co-activation molecules CD40, CD80, CD86, MHC-II on the surface of dendritic cells, stimulates the production of proinflammatory and regulatory cytokines and chemokines (IL-1, TNFα, IL-10, IL-12, IL-8, MCP-1, MIP-1, RANTES). It is proved that the activation of Immunomax NK cells is mediated by dendritic cells. Discovered effects suggest that the Immunomax activates the main physiological functions of dendritic cells such as antigen presentation T cells, activation of antigen-specific T cells, the involvement of other cell types in the inflammatory focus. It is assumed that the therapeutic effect of Immunomax in patients with various viral, bacterial and fungal infections, and cancer pathology may be due to the influence of dendritic cells.