Immunoreactive atrial natriuretic peptide in the retina of rats and rabbits

Donald E. Palm, Lanny C. Keil, Joseph W. Sassani, Walter B. Severs

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Immunoreactive atrial natriuretic peptide (ANP) has been detected in retinal tissue by radioimmunoassay, although it is unclear whether it was in retinal cells or represented residual peptide from blood and/or ocular fluids. We report here, using the immunoperoxidase method and a highly specific anti-rat ANP, that the peptide was localized consitently in the outer and inner plexiform layers of retinas of rats and rabbits. This information raises important issues: what are the implications for retinal function and, since blood-borne radioligands do not reveal retinal 'receptors', what is the endogenous target of retinal ANP?

Original languageEnglish (US)
Pages (from-to)142-144
Number of pages3
JournalBrain research
Issue number1
StatePublished - Dec 11 1989

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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