Immunoreactive atrial natriuretic peptide in the retina of rats and rabbits

Donald E. Palm; Lanny C. Keil; Joseph W. Sassani; Walter B. Severs

doi:10.1016/0006-8993(89)91612-0

Immunoreactive atrial natriuretic peptide in the retina of rats and rabbits

Donald E. Palm, Lanny C. Keil, Joseph W. Sassani, Walter B. Severs

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Immunoreactive atrial natriuretic peptide (ANP) has been detected in retinal tissue by radioimmunoassay, although it is unclear whether it was in retinal cells or represented residual peptide from blood and/or ocular fluids. We report here, using the immunoperoxidase method and a highly specific anti-rat ANP, that the peptide was localized consitently in the outer and inner plexiform layers of retinas of rats and rabbits. This information raises important issues: what are the implications for retinal function and, since blood-borne radioligands do not reveal retinal 'receptors', what is the endogenous target of retinal ANP?

Original language	English (US)
Pages (from-to)	142-144
Number of pages	3
Journal	Brain research
Volume	504
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(89)91612-0
State	Published - Dec 11 1989

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "Immunoreactive atrial natriuretic peptide in the retina of rats and rabbits",

abstract = "Immunoreactive atrial natriuretic peptide (ANP) has been detected in retinal tissue by radioimmunoassay, although it is unclear whether it was in retinal cells or represented residual peptide from blood and/or ocular fluids. We report here, using the immunoperoxidase method and a highly specific anti-rat ANP, that the peptide was localized consitently in the outer and inner plexiform layers of retinas of rats and rabbits. This information raises important issues: what are the implications for retinal function and, since blood-borne radioligands do not reveal retinal 'receptors', what is the endogenous target of retinal ANP?",

author = "Palm, {Donald E.} and Keil, {Lanny C.} and Sassani, {Joseph W.} and Severs, {Walter B.}",

note = "Funding Information: This work was supported by NASA-Ames Cooperative Agreement NCC-2-117 and NGT-70035.",

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T1 - Immunoreactive atrial natriuretic peptide in the retina of rats and rabbits

AU - Palm, Donald E.

AU - Keil, Lanny C.

AU - Sassani, Joseph W.

AU - Severs, Walter B.

N1 - Funding Information: This work was supported by NASA-Ames Cooperative Agreement NCC-2-117 and NGT-70035.

PY - 1989/12/11

Y1 - 1989/12/11

N2 - Immunoreactive atrial natriuretic peptide (ANP) has been detected in retinal tissue by radioimmunoassay, although it is unclear whether it was in retinal cells or represented residual peptide from blood and/or ocular fluids. We report here, using the immunoperoxidase method and a highly specific anti-rat ANP, that the peptide was localized consitently in the outer and inner plexiform layers of retinas of rats and rabbits. This information raises important issues: what are the implications for retinal function and, since blood-borne radioligands do not reveal retinal 'receptors', what is the endogenous target of retinal ANP?

AB - Immunoreactive atrial natriuretic peptide (ANP) has been detected in retinal tissue by radioimmunoassay, although it is unclear whether it was in retinal cells or represented residual peptide from blood and/or ocular fluids. We report here, using the immunoperoxidase method and a highly specific anti-rat ANP, that the peptide was localized consitently in the outer and inner plexiform layers of retinas of rats and rabbits. This information raises important issues: what are the implications for retinal function and, since blood-borne radioligands do not reveal retinal 'receptors', what is the endogenous target of retinal ANP?

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Immunoreactive atrial natriuretic peptide in the retina of rats and rabbits

Abstract

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