Abstract
The ability of the naturally occurring tumoricidal ellagitannin coriariin A to stimulate secretion of both IL-1β and TNF-α from human peripheral blood mononuclear cells has been demonstrated. Companion studies with the monomeric gallotannin β-D-pentagalloylglucose and a synthesized dimeric gallotannin-ellagitannin hybrid suggest that TNF-α rather than IL- 1β is the causative agent in tannin-mediated antitumor action in vivo, in contrast to an earlier proposal.
Original language | English (US) |
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Pages (from-to) | 985-990 |
Number of pages | 6 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 9 |
Issue number | 7 |
DOIs | |
State | Published - Apr 5 1999 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry