Immunostimulation by plant polyphenols: A relationship between tumor necrosis factor-α production and tannin structure

Ken S. Feldman; Kiran Sahasrabudhe; Randall S. Smith; William J. Scheuchenzuber

doi:10.1016/S0960-894X(99)00110-9

Immunostimulation by plant polyphenols: A relationship between tumor necrosis factor-α production and tannin structure

Ken S. Feldman
, Kiran Sahasrabudhe
, Randall S. Smith
, William J. Scheuchenzuber

Chemistry

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

The ability of the naturally occurring tumoricidal ellagitannin coriariin A to stimulate secretion of both IL-1β and TNF-α from human peripheral blood mononuclear cells has been demonstrated. Companion studies with the monomeric gallotannin β-D-pentagalloylglucose and a synthesized dimeric gallotannin-ellagitannin hybrid suggest that TNF-α rather than IL- 1β is the causative agent in tannin-mediated antitumor action in vivo, in contrast to an earlier proposal.

Original language	English (US)
Pages (from-to)	985-990
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	7
DOIs	https://doi.org/10.1016/S0960-894X(99)00110-9
State	Published - Apr 5 1999

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(99)00110-9

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title = "Immunostimulation by plant polyphenols: A relationship between tumor necrosis factor-α production and tannin structure",

abstract = "The ability of the naturally occurring tumoricidal ellagitannin coriariin A to stimulate secretion of both IL-1β and TNF-α from human peripheral blood mononuclear cells has been demonstrated. Companion studies with the monomeric gallotannin β-D-pentagalloylglucose and a synthesized dimeric gallotannin-ellagitannin hybrid suggest that TNF-α rather than IL- 1β is the causative agent in tannin-mediated antitumor action in vivo, in contrast to an earlier proposal.",

author = "Feldman, \{Ken S.\} and Kiran Sahasrabudhe and Smith, \{Randall S.\} and Scheuchenzuber, \{William J.\}",

note = "Funding Information: We thank the National Institutes of Health (GM35727) for support of this work.",

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T2 - A relationship between tumor necrosis factor-α production and tannin structure

AU - Feldman, Ken S.

AU - Sahasrabudhe, Kiran

AU - Smith, Randall S.

AU - Scheuchenzuber, William J.

N1 - Funding Information: We thank the National Institutes of Health (GM35727) for support of this work.

PY - 1999/4/5

Y1 - 1999/4/5

N2 - The ability of the naturally occurring tumoricidal ellagitannin coriariin A to stimulate secretion of both IL-1β and TNF-α from human peripheral blood mononuclear cells has been demonstrated. Companion studies with the monomeric gallotannin β-D-pentagalloylglucose and a synthesized dimeric gallotannin-ellagitannin hybrid suggest that TNF-α rather than IL- 1β is the causative agent in tannin-mediated antitumor action in vivo, in contrast to an earlier proposal.

AB - The ability of the naturally occurring tumoricidal ellagitannin coriariin A to stimulate secretion of both IL-1β and TNF-α from human peripheral blood mononuclear cells has been demonstrated. Companion studies with the monomeric gallotannin β-D-pentagalloylglucose and a synthesized dimeric gallotannin-ellagitannin hybrid suggest that TNF-α rather than IL- 1β is the causative agent in tannin-mediated antitumor action in vivo, in contrast to an earlier proposal.

UR - https://www.scopus.com/pages/publications/0033526108

UR - https://www.scopus.com/pages/publications/0033526108#tab=citedBy

U2 - 10.1016/S0960-894X(99)00110-9

DO - 10.1016/S0960-894X(99)00110-9

M3 - Article

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AN - SCOPUS:0033526108

SN - 0960-894X

VL - 9

SP - 985

EP - 990

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 7

ER -

Immunostimulation by plant polyphenols: A relationship between tumor necrosis factor-α production and tannin structure

Abstract

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