Immunosuppressive therapy of factor VIII inhibitors

M. B. Hultin, S. S. Shapiro, H. S. Bowman, F. M. Gill, A. T. Andrews, J. Martinez, E. M. Eyster, W. C. Sherwood

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Immunosuppressive therapy was used in seven hemophiliac and three nonhemophiliac patients with factor VIII inhibitors. Permanent disappearance of the inhibitor occurred in three hemophiliac and two nonhemophiliac patients following treatment with cyclophosphamide and factor VIII. Critical factors influencing the response to therapy may include both the titer and duration of the inhibitor and the degree of intervening factor VIII exposure prior to immunosuppressive therapy. Two severe hemophiliacs with low titer inhibitors that disappeared without specific therapy are also reported.

Original languageEnglish (US)
Pages (from-to)95-108
Number of pages14
JournalUnknown Journal
Issue number1
StatePublished - 1976

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology


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