Immunotherapy of tularemia: Characterization of a monoclonal antibody reactive with Francisella tularensis

R. B. Narayanan; Joseph Drabick; J. C. Williams; A. H. Fortier; M. S. Meltzer; J. C. Sadoff; C. R. Bolt; C. A. Nacy

doi:10.1002/jlb.53.1.112

Immunotherapy of tularemia: Characterization of a monoclonal antibody reactive with Francisella tularensis

R. B. Narayanan, Joseph Drabick, J. C. Williams, A. H. Fortier, M. S. Meltzer, J. C. Sadoff, C. R. Bolt, C. A. Nacy

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11 Scopus citations

Abstract

An IgM monoclonal antibody (mAb) recognized surface antigens specific to Francisella tularensis wild-type (Schu4) and live vaccine strain (LVS), and reacted with both in ELISA and slide agglutination tests. This mAb also reacted with LVS microorganisms in tissues of infected mice as assessed by an indirect fluorescence technique. Western blot analysis showed the mAb to react with antigens associated with F. tularensis LPS.

Original language	English (US)
Pages (from-to)	112-116
Number of pages	5
Journal	Journal of Leukocyte Biology
Volume	53
Issue number	1
DOIs	https://doi.org/10.1002/jlb.53.1.112
State	Published - 1993

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Cell Biology

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abstract = "An IgM monoclonal antibody (mAb) recognized surface antigens specific to Francisella tularensis wild-type (Schu4) and live vaccine strain (LVS), and reacted with both in ELISA and slide agglutination tests. This mAb also reacted with LVS microorganisms in tissues of infected mice as assessed by an indirect fluorescence technique. Western blot analysis showed the mAb to react with antigens associated with F. tularensis LPS.",

author = "Narayanan, {R. B.} and Joseph Drabick and Williams, {J. C.} and Fortier, {A. H.} and Meltzer, {M. S.} and Sadoff, {J. C.} and Bolt, {C. R.} and Nacy, {C. A.}",

year = "1993",

doi = "10.1002/jlb.53.1.112",

language = "English (US)",

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T2 - Characterization of a monoclonal antibody reactive with Francisella tularensis

AU - Narayanan, R. B.

AU - Drabick, Joseph

AU - Williams, J. C.

AU - Fortier, A. H.

AU - Meltzer, M. S.

AU - Sadoff, J. C.

AU - Bolt, C. R.

AU - Nacy, C. A.

PY - 1993

Y1 - 1993

N2 - An IgM monoclonal antibody (mAb) recognized surface antigens specific to Francisella tularensis wild-type (Schu4) and live vaccine strain (LVS), and reacted with both in ELISA and slide agglutination tests. This mAb also reacted with LVS microorganisms in tissues of infected mice as assessed by an indirect fluorescence technique. Western blot analysis showed the mAb to react with antigens associated with F. tularensis LPS.

AB - An IgM monoclonal antibody (mAb) recognized surface antigens specific to Francisella tularensis wild-type (Schu4) and live vaccine strain (LVS), and reacted with both in ELISA and slide agglutination tests. This mAb also reacted with LVS microorganisms in tissues of infected mice as assessed by an indirect fluorescence technique. Western blot analysis showed the mAb to react with antigens associated with F. tularensis LPS.

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Immunotherapy of tularemia: Characterization of a monoclonal antibody reactive with Francisella tularensis

Abstract

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