Impact of AJCC 8th edition staging system and definitive treatment choice on the prognosis of complete responders with p16+ and p16− oropharyngeal squamous cell carcinomas

R. Grant Muller, Chelsea S. Hamill, Brandon Vu, Jason Thuener, Jay Wasman, Shawn Li, Nicole Fowler, Rod Rezaee, Pierre Lavertu, Min Yao, Kyunghee Burkitt, Jennifer Dorth, Theodoros N. Teknos, Quintin Pan, W. Quinn O'Neill

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objectives: To identify predictors of overall survival (OS) in oropharyngeal squamous cell carcinoma (OPSCC) patients who achieved complete response (CR). Methods: We performed a retrospective study of OPSCC patients who achieved CR from a single academic medical center. Associations between OS, AJCC 8th edition staging system, definitive treatment choice, smoking history, and p16 status were assessed. Results: p16+ status was associated with favorable prognosis for CR (p < 0.001) but not non-CR (p = 0.67) patients. For early stage, p16+ OPSCC patients who achieved CR, surgery + adjuvant radiation (RT) treatment was more durable compared to concurrent chemoradiation (CRT), particularly in smokers. Conclusions: Curative intent treatment choice and smoking history has an impact on the long-term OS of the CR p16+ OPSCC cohort. Prospective studies to define the optimal multi-modality treatment option to manage p16+ OPSCC patients is needed.

Original languageEnglish (US)
Article number105861
JournalOral Oncology
Volume128
DOIs
StatePublished - May 2022

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Oncology
  • Cancer Research

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