TY - JOUR
T1 - Impact of Pulsatile Perfusion on Clinical Outcomes of Neonates and Infants With Complex Pathologies Undergoing Cardiopulmonary Bypass Procedures
AU - Alkan-Bozkaya, Tijen
AU - Akçevin, Atif
AU - Türkoǧlu, Halil
AU - Ündar, Akif
PY - 2013/1
Y1 - 2013/1
N2 - The aim of this clinical trial was to evaluate the pulsatile perfusion mode in pediatric patients who had complex cardiac pathologies according to Jenkins stratifications (category 4) undergoing cardiopulmonary bypass procedures (CPB). Patients with transposition of great arteries (TGA) and ventricular septal defect (VSD) were included in this clinical study. Eighty-nine consecutive pediatric patients undergoing open heart surgery for repair of TGA-VSD were prospectively entered into the study and were randomly assigned to either the pulsatile perfusion group (Group P, n=58) or the nonpulsatile perfusion group (Group NP, n=31). There were no differences between groups in terms of demographical and intraoperative parameters. The pulsatile group needed significantly less inotropic support (P<0.05) and had lower lactate levels (P<0.001), higher urine output (P<0.01), and higher albumin levels (P<0.05). In addition, the pulsatile group had less ICU (P<0.01) and hospital stays (P<0.001). We conclude that the use of pulsatile flow is a better option and should be considered for repair of the complex congenital heart defects.
AB - The aim of this clinical trial was to evaluate the pulsatile perfusion mode in pediatric patients who had complex cardiac pathologies according to Jenkins stratifications (category 4) undergoing cardiopulmonary bypass procedures (CPB). Patients with transposition of great arteries (TGA) and ventricular septal defect (VSD) were included in this clinical study. Eighty-nine consecutive pediatric patients undergoing open heart surgery for repair of TGA-VSD were prospectively entered into the study and were randomly assigned to either the pulsatile perfusion group (Group P, n=58) or the nonpulsatile perfusion group (Group NP, n=31). There were no differences between groups in terms of demographical and intraoperative parameters. The pulsatile group needed significantly less inotropic support (P<0.05) and had lower lactate levels (P<0.001), higher urine output (P<0.01), and higher albumin levels (P<0.05). In addition, the pulsatile group had less ICU (P<0.01) and hospital stays (P<0.001). We conclude that the use of pulsatile flow is a better option and should be considered for repair of the complex congenital heart defects.
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U2 - 10.1111/j.1525-1594.2012.01552.x
DO - 10.1111/j.1525-1594.2012.01552.x
M3 - Article
C2 - 23145894
AN - SCOPUS:84872404314
SN - 0160-564X
VL - 37
SP - 82
EP - 86
JO - Artificial organs
JF - Artificial organs
IS - 1
ER -