TY - JOUR
T1 - Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)α and PPARβ mutant mice
AU - Michalik, Liliane
AU - Desvergne, Béatrice
AU - Tan, Nguan Soon
AU - Basu-Modak, Sharmila
AU - Escher, Pascal
AU - Rieusset, Jennifer
AU - Peters, Jeffrey M.
AU - Kaya, Gürkan
AU - Gonzalez, Frank J.
AU - Zakany, Jozsef
AU - Metzger, Daniel
AU - Chambon, Pierre
AU - Duboule, Denis
AU - Wahli, Walter
PY - 2001/8/20
Y1 - 2001/8/20
N2 - We show here that the α, β, and γ isotypes of peroxisome proliferator-activated receptor (PPAR) are expressed in the mouse epidermis during fetal development and that they disappear progressively from the interfollicular epithelium after birth. Interestingly, PPARα and β expression is reactivated in the adult epidermis after various stimuli, resulting in keratinocyte proliferation and differentiation such as tetradecanoylphorbol acetate topical application, hair plucking, or skin wound healing. Using PPARα, β, and γ mutant mice, we demonstrate that PPARα and β are important for the rapid epithelialization of a skin wound and that each of them plays a specific role in this process. PPARα is mainly involved in the early inflammation phase of the healing, whereas PPARβ is implicated in the control of keratinocyte proliferation. In addition and very interestingly, PPARβ mutant primary keratinocytes show impaired adhesion and migration properties. Thus, the findings presented here reveal unpredicted roles for PPARα and β in adult mouse epidermal repair.
AB - We show here that the α, β, and γ isotypes of peroxisome proliferator-activated receptor (PPAR) are expressed in the mouse epidermis during fetal development and that they disappear progressively from the interfollicular epithelium after birth. Interestingly, PPARα and β expression is reactivated in the adult epidermis after various stimuli, resulting in keratinocyte proliferation and differentiation such as tetradecanoylphorbol acetate topical application, hair plucking, or skin wound healing. Using PPARα, β, and γ mutant mice, we demonstrate that PPARα and β are important for the rapid epithelialization of a skin wound and that each of them plays a specific role in this process. PPARα is mainly involved in the early inflammation phase of the healing, whereas PPARβ is implicated in the control of keratinocyte proliferation. In addition and very interestingly, PPARβ mutant primary keratinocytes show impaired adhesion and migration properties. Thus, the findings presented here reveal unpredicted roles for PPARα and β in adult mouse epidermal repair.
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U2 - 10.1083/jcb.200011148
DO - 10.1083/jcb.200011148
M3 - Article
C2 - 11514592
AN - SCOPUS:0035921419
SN - 0021-9525
VL - 154
SP - 799
EP - 814
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 4
ER -