TY - JOUR
T1 - Implication of auditory confounding in interpreting somatosensory and motor responses in low-intensity focused transcranial ultrasound stimulation
AU - Park, Christine
AU - Chen, Mengyue
AU - Kim, Taewon
N1 - Publisher Copyright:
Copyright © 2021 the American Physiological Society
PY - 2021
Y1 - 2021
N2 - Low-intensity transcranial focused ultrasound (LI-tFUS) stimulation is a noninvasive neuromodulation tool that demonstrates high target localization accuracy and depth penetration. It has been shown to modulate activities in the primary motor and somatosensory cortex. Previous studies in animals as well as in humans, illustrated in the recently published paper in Brain Stimulation by Braun et al. [Braun V, Blackmore J, Cleveland RO, Butler CR. Brain Stimul 13: 1527–1534, 2020], acknowledged the possibility of indirect stimulation of the peripheral auditory pathway that could confound the somatosensory and motor responses observed with LI-tFUS stimulation. Here, we discuss the implications and interpretations of auditory confounding in the context of neuromodulation.
AB - Low-intensity transcranial focused ultrasound (LI-tFUS) stimulation is a noninvasive neuromodulation tool that demonstrates high target localization accuracy and depth penetration. It has been shown to modulate activities in the primary motor and somatosensory cortex. Previous studies in animals as well as in humans, illustrated in the recently published paper in Brain Stimulation by Braun et al. [Braun V, Blackmore J, Cleveland RO, Butler CR. Brain Stimul 13: 1527–1534, 2020], acknowledged the possibility of indirect stimulation of the peripheral auditory pathway that could confound the somatosensory and motor responses observed with LI-tFUS stimulation. Here, we discuss the implications and interpretations of auditory confounding in the context of neuromodulation.
UR - http://www.scopus.com/inward/record.url?scp=85108056037&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85108056037&partnerID=8YFLogxK
U2 - 10.1152/jn.00701.2020
DO - 10.1152/jn.00701.2020
M3 - Article
C2 - 33978511
AN - SCOPUS:85108056037
SN - 0022-3077
VL - 125
SP - 2356
EP - 2360
JO - Journal of neurophysiology
JF - Journal of neurophysiology
IS - 6
ER -