TY - JOUR
T1 - Importance of asymmetric structure in determining mass transport characteristics of hollow fiber hemodialyzers
AU - Morti, Stavroula
AU - Shao, Jiahui
AU - Zydney, Andrew L.
N1 - Funding Information:
The authors would like to thank W.R. Grace for the donation of the automated dialysis system, Fresenius Medical Care and Baxter Healthcare for providing the hollow fiber dialyzers, and Fresenius Medical Care and Novaflux Technologies for their financial support.
PY - 2003/10/15
Y1 - 2003/10/15
N2 - Most synthetic hemodialysis membranes have an asymmetric structure consisting of a thin semi-permeable skin and a more open support structure. The impact of this asymmetric structure on the transport characteristics of hemodialysis membranes has not been appreciated. Experimental data were obtained for solute clearance and sieving through asymmetric polysulfone membranes and homogeneous cellulose triacetate hollow fiber membranes. The clearance of urea and the large molecular weight dextrans were greater for the cellulose triacetate membrane compared to the polysulfone, but the clearance of the smaller molecular weight dextrans was slightly greater for the polysulfone dialyzer. The sieving coefficients for the asymmetric membrane were uniformly smaller than those for the homogeneous membrane, although this effect was dramatically reduced at very small filtration velocities. These results were in good agreement with theoretical calculations based on a two-layer model for the asymmetric membrane and available hydrodynamic descriptions of hindered solute transport.
AB - Most synthetic hemodialysis membranes have an asymmetric structure consisting of a thin semi-permeable skin and a more open support structure. The impact of this asymmetric structure on the transport characteristics of hemodialysis membranes has not been appreciated. Experimental data were obtained for solute clearance and sieving through asymmetric polysulfone membranes and homogeneous cellulose triacetate hollow fiber membranes. The clearance of urea and the large molecular weight dextrans were greater for the cellulose triacetate membrane compared to the polysulfone, but the clearance of the smaller molecular weight dextrans was slightly greater for the polysulfone dialyzer. The sieving coefficients for the asymmetric membrane were uniformly smaller than those for the homogeneous membrane, although this effect was dramatically reduced at very small filtration velocities. These results were in good agreement with theoretical calculations based on a two-layer model for the asymmetric membrane and available hydrodynamic descriptions of hindered solute transport.
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U2 - 10.1016/j.memsci.2003.06.001
DO - 10.1016/j.memsci.2003.06.001
M3 - Article
AN - SCOPUS:0142011024
SN - 0376-7388
VL - 224
SP - 39
EP - 49
JO - Journal of Membrane Science
JF - Journal of Membrane Science
IS - 1-2
ER -