TY - JOUR
T1 - Improved micromachined column design and fluidic interconnects for programmed high-temperature gas chromatography separations
AU - Gaddes, David
AU - Westland, Jessica
AU - Dorman, Frank L.
AU - Tadigadapa, Srinivas
N1 - Funding Information:
The authors would like to the directors of the Materials Research Institute and the Huck Life Sciences Institute at the Pennsylvania State University for the financial support for this work.
PY - 2014/7/4
Y1 - 2014/7/4
N2 - This work focuses on the development and experimental evaluation of micromachined chromatographic columns for use in a commercial gas chromatography (GC) system. A vespel/graphite ferrule based compression sealing technique is presented using which leak-proof fluidic interconnection between the inlet tubing and the microchannel was achieved. This sealing technique enabled separation at temperatures up to 350. °C on a μGC column. This paper reports the first high-temperature separations in microfabricated chromatographic columns at these temperatures. A 2. m microfabricated column using a double Archimedean spiral design with a square cross-section of 100. μm. ×. 100. μm has been developed using silicon microfabrication techniques. The microfabricated column was benchmarked against a 2. m 100. μm diameter commercial column and the performance between the two columns was evaluated in tests performed under identical conditions. High temperature separations of simulated distillation (ASTM2887) and polycyclic aromatic hydrocarbons (EPA8310) were performed using the μGC column in temperature programmed mode. The demonstrated μGC column along with the high temperature fixture offers one more solution toward potentially realizing a portable μGC device for the detection of semi-volatile environmental pollutants and explosives without the thermal limitations reported to date with μGC columns using epoxy based interconnect technology.
AB - This work focuses on the development and experimental evaluation of micromachined chromatographic columns for use in a commercial gas chromatography (GC) system. A vespel/graphite ferrule based compression sealing technique is presented using which leak-proof fluidic interconnection between the inlet tubing and the microchannel was achieved. This sealing technique enabled separation at temperatures up to 350. °C on a μGC column. This paper reports the first high-temperature separations in microfabricated chromatographic columns at these temperatures. A 2. m microfabricated column using a double Archimedean spiral design with a square cross-section of 100. μm. ×. 100. μm has been developed using silicon microfabrication techniques. The microfabricated column was benchmarked against a 2. m 100. μm diameter commercial column and the performance between the two columns was evaluated in tests performed under identical conditions. High temperature separations of simulated distillation (ASTM2887) and polycyclic aromatic hydrocarbons (EPA8310) were performed using the μGC column in temperature programmed mode. The demonstrated μGC column along with the high temperature fixture offers one more solution toward potentially realizing a portable μGC device for the detection of semi-volatile environmental pollutants and explosives without the thermal limitations reported to date with μGC columns using epoxy based interconnect technology.
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U2 - 10.1016/j.chroma.2014.04.087
DO - 10.1016/j.chroma.2014.04.087
M3 - Article
C2 - 24866564
AN - SCOPUS:84901639225
SN - 0021-9673
VL - 1349
SP - 96
EP - 104
JO - Journal of Chromatography A
JF - Journal of Chromatography A
ER -