Improved protocol for indoline synthesis via palladium-catalyzed intramolecular C(sp 2)-H amination

Gang He; Chengxi Lu; Yingsheng Zhao; William A. Nack; Gong Chen

doi:10.1021/ol301352v

Improved protocol for indoline synthesis via palladium-catalyzed intramolecular C(sp ²)-H amination

Gang He, Chengxi Lu, Yingsheng Zhao, William A. Nack, Gong Chen

Chemistry

Research output: Contribution to journal › Article › peer-review

154 Scopus citations

Abstract

An efficient method has been developed for the synthesis of indoline compounds from picolinamide (PA)-protected β-arylethylamine substrates via palladium-catalyzed intramolecular amination of ortho-C(sp ²)-H bonds. These reactions feature high efficiency, low catalyst loadings, mild operating conditions, and the use of inexpensive reagents.

Original language	English (US)
Pages (from-to)	2944-2947
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	12
DOIs	https://doi.org/10.1021/ol301352v
State	Published - Jun 15 2012

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol301352v

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title = "Improved protocol for indoline synthesis via palladium-catalyzed intramolecular C(sp 2)-H amination",

abstract = "An efficient method has been developed for the synthesis of indoline compounds from picolinamide (PA)-protected β-arylethylamine substrates via palladium-catalyzed intramolecular amination of ortho-C(sp 2)-H bonds. These reactions feature high efficiency, low catalyst loadings, mild operating conditions, and the use of inexpensive reagents.",

author = "Gang He and Chengxi Lu and Yingsheng Zhao and Nack, \{William A.\} and Gong Chen",

year = "2012",

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doi = "10.1021/ol301352v",

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AU - He, Gang

AU - Lu, Chengxi

AU - Zhao, Yingsheng

AU - Nack, William A.

AU - Chen, Gong

PY - 2012/6/15

Y1 - 2012/6/15

N2 - An efficient method has been developed for the synthesis of indoline compounds from picolinamide (PA)-protected β-arylethylamine substrates via palladium-catalyzed intramolecular amination of ortho-C(sp 2)-H bonds. These reactions feature high efficiency, low catalyst loadings, mild operating conditions, and the use of inexpensive reagents.

AB - An efficient method has been developed for the synthesis of indoline compounds from picolinamide (PA)-protected β-arylethylamine substrates via palladium-catalyzed intramolecular amination of ortho-C(sp 2)-H bonds. These reactions feature high efficiency, low catalyst loadings, mild operating conditions, and the use of inexpensive reagents.

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JO - Organic Letters

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ER -

Improved protocol for indoline synthesis via palladium-catalyzed intramolecular C(sp ²)-H amination

Abstract

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