Improved time efficiency and accuracy in diffusion tensor microimaging with multiple-echo acquisition

Vikas Gulani; Thomas Weber; Thomas Neuberger; Andrew G. Webb

doi:10.1016/j.jmr.2005.08.007

Improved time efficiency and accuracy in diffusion tensor microimaging with multiple-echo acquisition

Vikas Gulani, Thomas Weber, Thomas Neuberger, Andrew G. Webb

Huck Institutes of the Life Sciences

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

In high-field NMR microscopy rapid single-shot imaging methods, for example, echo planar imaging, cannot be used for determination of the apparent diffusion tensor (ADT) due to large magnetic susceptibility effects. We propose a pulse sequence in which a diffusion-weighted spin-echo is followed by multiple gradient-echoes with additional diffusion weighting. These additional echoes can be used to calculate the ADT and T*₂ maps. We show here that this results in modest but consistent improvements in the accuracy of ADT determination within a given total data acquisition time. The method is tested on excised, chemically fixed rat spinal cords.

Original language	English (US)
Pages (from-to)	329-335
Number of pages	7
Journal	Journal of Magnetic Resonance
Volume	177
Issue number	2
DOIs	https://doi.org/10.1016/j.jmr.2005.08.007
State	Published - Dec 2005

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Nuclear and High Energy Physics
Condensed Matter Physics

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10.1016/j.jmr.2005.08.007

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@article{452fec8723d245b9ac4c0d1b1d8711aa,

title = "Improved time efficiency and accuracy in diffusion tensor microimaging with multiple-echo acquisition",

abstract = "In high-field NMR microscopy rapid single-shot imaging methods, for example, echo planar imaging, cannot be used for determination of the apparent diffusion tensor (ADT) due to large magnetic susceptibility effects. We propose a pulse sequence in which a diffusion-weighted spin-echo is followed by multiple gradient-echoes with additional diffusion weighting. These additional echoes can be used to calculate the ADT and T*2 maps. We show here that this results in modest but consistent improvements in the accuracy of ADT determination within a given total data acquisition time. The method is tested on excised, chemically fixed rat spinal cords.",

author = "Vikas Gulani and Thomas Weber and Thomas Neuberger and Webb, \{Andrew G.\}",

note = "Funding Information: We thank Andre M{\"u}ller from the Neurology Department of the University Hospital in Regensburg, Germany, for providing us with the spinal cord samples. V.G., T.N., and A.W. gratefully acknowledge the financial support of the Alexander von Humboldt Stiftung, Wolfgang Paul Preis. The authors thank the reviewers for their help in improving the manuscript, and in particular, for their suggestion of the addition of Table 1 to simplify for the reader the various gradient configurations employed here. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2005",

month = dec,

doi = "10.1016/j.jmr.2005.08.007",

language = "English (US)",

volume = "177",

pages = "329--335",

journal = "Journal of Magnetic Resonance",

issn = "1090-7807",

publisher = "Academic Press Inc.",

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T1 - Improved time efficiency and accuracy in diffusion tensor microimaging with multiple-echo acquisition

AU - Gulani, Vikas

AU - Weber, Thomas

AU - Neuberger, Thomas

AU - Webb, Andrew G.

N1 - Funding Information: We thank Andre Müller from the Neurology Department of the University Hospital in Regensburg, Germany, for providing us with the spinal cord samples. V.G., T.N., and A.W. gratefully acknowledge the financial support of the Alexander von Humboldt Stiftung, Wolfgang Paul Preis. The authors thank the reviewers for their help in improving the manuscript, and in particular, for their suggestion of the addition of Table 1 to simplify for the reader the various gradient configurations employed here. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2005/12

Y1 - 2005/12

N2 - In high-field NMR microscopy rapid single-shot imaging methods, for example, echo planar imaging, cannot be used for determination of the apparent diffusion tensor (ADT) due to large magnetic susceptibility effects. We propose a pulse sequence in which a diffusion-weighted spin-echo is followed by multiple gradient-echoes with additional diffusion weighting. These additional echoes can be used to calculate the ADT and T*2 maps. We show here that this results in modest but consistent improvements in the accuracy of ADT determination within a given total data acquisition time. The method is tested on excised, chemically fixed rat spinal cords.

AB - In high-field NMR microscopy rapid single-shot imaging methods, for example, echo planar imaging, cannot be used for determination of the apparent diffusion tensor (ADT) due to large magnetic susceptibility effects. We propose a pulse sequence in which a diffusion-weighted spin-echo is followed by multiple gradient-echoes with additional diffusion weighting. These additional echoes can be used to calculate the ADT and T*2 maps. We show here that this results in modest but consistent improvements in the accuracy of ADT determination within a given total data acquisition time. The method is tested on excised, chemically fixed rat spinal cords.

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JO - Journal of Magnetic Resonance

JF - Journal of Magnetic Resonance

IS - 2

ER -

Improved time efficiency and accuracy in diffusion tensor microimaging with multiple-echo acquisition

Abstract

All Science Journal Classification (ASJC) codes

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