Improvement in vulvar vestibulitis with montelukast

Neha Kamdar, Laura Fisher, Colin MacNeill

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


OBJECTIVE: To determine if montelukast treatment improves symptoms in patients with vulvar vestibulitis. STUDY DESIGN: We administered montelukast to a series of patients with vestibulitis seen at the Pennsylvania State University Vulvodynia Clinic over a period of 2.5 years. We reviewed outcomes using a scoring scheme to quantify signs and symptoms, before and after treat-ment, in 29 montelukast-treated subjects and 18 subjects in a comparison group treated with standard therapies. RESULTS: Subjects treated with montelukast showed an average of 52% in improvement in symptoms as compared to a 15% improvement in the controls (p <0.0001). CONCLUSION: Montelukast is a viable treatment option for women with vulvar vestibulitis. This finding implies that leukotrienes have a role in the pathophysiology of vulvar vestibulitis.

Original languageEnglish (US)
Pages (from-to)912-916
Number of pages5
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number10
StatePublished - Oct 2007

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology


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