Improving phage therapy by evasion of phage resistance mechanisms

Inés Bleriot, Olga Pacios, Lucia Blasco, Laura Fernández-García, María López, Concha Ortiz-Cartagena, Antonio Barrio-Pujante, Rodolfo García-Contreras, Jean Paul Pirnay, Thomas K. Wood, María Tomás

Research output: Contribution to journalReview articlepeer-review

Abstract

Antibiotic failure is one of the most worrisome threats to global health. Among the new therapeutic efforts that are being explored, the use of bacteriophages (viruses that kill bacteria), also known as ‘phages’, is being extensively studied as a strategy to target bacterial pathogens. However, one of the main drawbacks of phage therapy is the plethora of defence mechanisms that bacteria use to defend themselves against phages. This review aims to summarize the therapeutic approaches that are being evaluated to overcome the bacterial defence systems, including the most innovative therapeutic approaches applied: circumvention of phage receptor mutations; modification of prophages; targeting of CRISPR-Cas systems and the biofilm matrix; engineering of safer and more efficacious phages; and inhibition of the anti-persister strategies used by bacteria.

Original languageEnglish (US)
Article numberdlae017
JournalJAC-Antimicrobial Resistance
Volume6
Issue number1
DOIs
StatePublished - Feb 1 2024

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology and Allergy
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

Cite this