Improving secondary ion mass spectrometry image quality with image fusion

Jay G. Tarolli, Lauren M. Jackson, Nicholas Winograd

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


The spatial resolution of chemical images acquired with cluster secondary ion mass spectrometry (SIMS) is limited not only by the size of the probe utilized to create the images but also by detection sensitivity. As the probe size is reduced to below 1 μm, for example, a low signal in each pixel limits lateral resolution because of counting statistics considerations. Although it can be useful to implement numerical methods to mitigate this problem, here we investigate the use of image fusion to combine information from scanning electron microscope (SEM) data with chemically resolved SIMS images. The advantage of this approach is that the higher intensity and, hence, spatial resolution of the electron images can help to improve the quality of the SIMS images without sacrificing chemical specificity. Using a pan-sharpening algorithm, the method is illustrated using synthetic data, experimental data acquired from a metallic grid sample, and experimental data acquired from a lawn of algae cells. The results show that up to an order of magnitude increase in spatial resolution is possible to achieve. A cross-correlation metric is utilized for evaluating the reliability of the procedure. [Figure not available: see fulltext.]

Original languageEnglish (US)
Pages (from-to)2154-2162
Number of pages9
JournalJournal of the American Society for Mass Spectrometry
Issue number12
StatePublished - Dec 2014

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Spectroscopy


Dive into the research topics of 'Improving secondary ion mass spectrometry image quality with image fusion'. Together they form a unique fingerprint.

Cite this