In vitro activity of tigecycline against multidrug-resistant Acinetobacter baumannii and selection of tigecycline-amikacin synergy

Ellen S. Moland; David W. Craft; Seong Geun Hong; Soo Young Kim; Lucas Hachmeister; Shimon D. Sayed; Kenneth S. Thomson

doi:10.1128/AAC.01581-07

In vitro activity of tigecycline against multidrug-resistant Acinetobacter baumannii and selection of tigecycline-amikacin synergy

Ellen S. Moland, David W. Craft, Seong Geun Hong, Soo Young Kim, Lucas Hachmeister, Shimon D. Sayed, Kenneth S. Thomson

Department of Pathology and Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Polymyxin B, minocycline, and tigecycline were the most potent of 10 antibiotics against 170 isolates of multidrug-resistant Acinetobacter baumannii. In time-kill studies, the exposure of a highly tigecycline-resistant isolate to tigecycline resulted in enhanced susceptibility to amikacin and synergistic bactericidal activities of the two drugs.

Original language	English (US)
Pages (from-to)	2940-2942
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	52
Issue number	8
DOIs	https://doi.org/10.1128/AAC.01581-07
State	Published - Aug 2008

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.01581-07

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abstract = "Polymyxin B, minocycline, and tigecycline were the most potent of 10 antibiotics against 170 isolates of multidrug-resistant Acinetobacter baumannii. In time-kill studies, the exposure of a highly tigecycline-resistant isolate to tigecycline resulted in enhanced susceptibility to amikacin and synergistic bactericidal activities of the two drugs.",

author = "Moland, {Ellen S.} and Craft, {David W.} and Hong, {Seong Geun} and Kim, {Soo Young} and Lucas Hachmeister and Sayed, {Shimon D.} and Thomson, {Kenneth S.}",

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AU - Moland, Ellen S.

AU - Craft, David W.

AU - Hong, Seong Geun

AU - Kim, Soo Young

AU - Hachmeister, Lucas

AU - Sayed, Shimon D.

AU - Thomson, Kenneth S.

PY - 2008/8

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AB - Polymyxin B, minocycline, and tigecycline were the most potent of 10 antibiotics against 170 isolates of multidrug-resistant Acinetobacter baumannii. In time-kill studies, the exposure of a highly tigecycline-resistant isolate to tigecycline resulted in enhanced susceptibility to amikacin and synergistic bactericidal activities of the two drugs.

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In vitro activity of tigecycline against multidrug-resistant Acinetobacter baumannii and selection of tigecycline-amikacin synergy

Abstract

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