In vitro and in vivo inhibition of LPS-stimulated tumor necrosis factor-α secretion by the gallotannin β-D-pentagalloylglucose

Ken S. Feldman; Kiran Sahasrabudhe; Michael D. Lawlor; Sarah L. Wilson; Charles H. Lang; William J. Scheuchenzuber

doi:10.1016/S0960-894X(01)00332-8

In vitro and in vivo inhibition of LPS-stimulated tumor necrosis factor-α secretion by the gallotannin β-D-pentagalloylglucose

Ken S. Feldman
, Kiran Sahasrabudhe
, Michael D. Lawlor
, Sarah L. Wilson
, Charles H. Lang
, William J. Scheuchenzuber

Chemistry

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

The naturally occurring gallotannin β-D-pentagalloylglucose (β-PGG) decreases tumor necrosis factor-alpha (TNF-α) output from human peripheral blood mononucleocytes exposed to lipopolysaccharide (LPS) by as much as 90% (vs control) at ∼5 μM concentration. A qualitatively similar but less pronounced effect (∼50% decrease) was observed in the serum of rats dosed with both LPS and β-PGG. These results may have relevance to therapies that target disease states characterized by an overproduction of TNF-α.

Original language	English (US)
Pages (from-to)	1813-1815
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	14
DOIs	https://doi.org/10.1016/S0960-894X(01)00332-8
State	Published - Jul 23 2001

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0960-894X(01)00332-8

Cite this

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title = "In vitro and in vivo inhibition of LPS-stimulated tumor necrosis factor-α secretion by the gallotannin β-D-pentagalloylglucose",

abstract = "The naturally occurring gallotannin β-D-pentagalloylglucose (β-PGG) decreases tumor necrosis factor-alpha (TNF-α) output from human peripheral blood mononucleocytes exposed to lipopolysaccharide (LPS) by as much as 90\% (vs control) at ∼5 μM concentration. A qualitatively similar but less pronounced effect (∼50\% decrease) was observed in the serum of rats dosed with both LPS and β-PGG. These results may have relevance to therapies that target disease states characterized by an overproduction of TNF-α.",

author = "Feldman, \{Ken S.\} and Kiran Sahasrabudhe and Lawlor, \{Michael D.\} and Wilson, \{Sarah L.\} and Lang, \{Charles H.\} and Scheuchenzuber, \{William J.\}",

note = "Funding Information: The authors thank the National Institutes of Health (GM 35727 (KSF), GM 38032 (CHL)) for financial support of this work.",

year = "2001",

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doi = "10.1016/S0960-894X(01)00332-8",

language = "English (US)",

volume = "11",

pages = "1813--1815",

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TY - JOUR

T1 - In vitro and in vivo inhibition of LPS-stimulated tumor necrosis factor-α secretion by the gallotannin β-D-pentagalloylglucose

AU - Feldman, Ken S.

AU - Sahasrabudhe, Kiran

AU - Lawlor, Michael D.

AU - Wilson, Sarah L.

AU - Lang, Charles H.

AU - Scheuchenzuber, William J.

N1 - Funding Information: The authors thank the National Institutes of Health (GM 35727 (KSF), GM 38032 (CHL)) for financial support of this work.

PY - 2001/7/23

Y1 - 2001/7/23

N2 - The naturally occurring gallotannin β-D-pentagalloylglucose (β-PGG) decreases tumor necrosis factor-alpha (TNF-α) output from human peripheral blood mononucleocytes exposed to lipopolysaccharide (LPS) by as much as 90% (vs control) at ∼5 μM concentration. A qualitatively similar but less pronounced effect (∼50% decrease) was observed in the serum of rats dosed with both LPS and β-PGG. These results may have relevance to therapies that target disease states characterized by an overproduction of TNF-α.

AB - The naturally occurring gallotannin β-D-pentagalloylglucose (β-PGG) decreases tumor necrosis factor-alpha (TNF-α) output from human peripheral blood mononucleocytes exposed to lipopolysaccharide (LPS) by as much as 90% (vs control) at ∼5 μM concentration. A qualitatively similar but less pronounced effect (∼50% decrease) was observed in the serum of rats dosed with both LPS and β-PGG. These results may have relevance to therapies that target disease states characterized by an overproduction of TNF-α.

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U2 - 10.1016/S0960-894X(01)00332-8

DO - 10.1016/S0960-894X(01)00332-8

M3 - Article

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AN - SCOPUS:0035939246

SN - 0960-894X

VL - 11

SP - 1813

EP - 1815

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 14

ER -

In vitro and in vivo inhibition of LPS-stimulated tumor necrosis factor-α secretion by the gallotannin β-D-pentagalloylglucose

Abstract

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