TY - JOUR
T1 - In-Vitro and In-Vivo trans-scalp evaluation of an intracranial pressure implant at 2.4 GHz
AU - Kawoos, Usmah
AU - Tofighi, Mohammad Reza
AU - Warty, Ruchi
AU - Kralick, Francis A.
AU - Rosen, Arye
N1 - Funding Information:
Manuscript received February 27, 2008; revised June 12, 2008. First published September 23, 2008; current version published October 8, 2008. This work was supported by the National Institutes of Health (NIH) under Grant R21 NS050590-01. U. Kawoos and A. Rosen are with the School of Biomedical Engineering, Drexel University, Philadelphia, PA 19104 USA (e-mail: [email protected]; [email protected]). M.-R. Tofighi is with Capital College, Pennsylvania State University, Mid-dletown, 17057 PA USA (e-mail: [email protected]). R. Warty was with the Department of Electrical Engineering, Drexel University, Philadelphia, PA 19104 USA. She is now with Hughes Network Systems LLC, Germantown, MD 20876 USA (e-mail: [email protected]). F. A. Kralick is with the Neurosurgery Department, College of Medicine, Drexel University, Philadelphia, PA 19102 USA (e-mail: [email protected]) Color versions of one or more of the figures in this paper are available online at http://ieeexplore.ieee.org. Digital Object Identifier 10.1109/TMTT.2008.2004253
PY - 2008/10
Y1 - 2008/10
N2 - Elevation of intracranial pressure is one of the most important issues in neurosurgery and neurology in clinical practice. The prevalent techniques for measuring intracranial pressure require equipments that are wired, restricted to a hospital environment, and cause patient discomfort. A novel method for measuring the intracranial pressure is described. A wireless completely implantable device, operating at an industrial-scientific-medical band of 2.4 GHz, has been developed and tested. In-vitro and in-vivo evaluations are described to demonstrate the feasibility of microwave pressure monitoring through scalp, device integrity over a long period of time, and repeatability of pressure measurements. A distinction between an epidural and sub-dural pressure monitoring techniques is also described. Histo-pathological results obtained upon a long-term device implantation favor the utilization of the sub-dural pressure monitoring method. On the other hand, in-vivo studies illustrate a maximum pressure reading error of 0.8 mm · Hg obtained for a sub-dural device with a capacitive microelectromechanical system sensor compared to 2 mm · Hg obtained for an epidural device with a piezoresistive sensor.
AB - Elevation of intracranial pressure is one of the most important issues in neurosurgery and neurology in clinical practice. The prevalent techniques for measuring intracranial pressure require equipments that are wired, restricted to a hospital environment, and cause patient discomfort. A novel method for measuring the intracranial pressure is described. A wireless completely implantable device, operating at an industrial-scientific-medical band of 2.4 GHz, has been developed and tested. In-vitro and in-vivo evaluations are described to demonstrate the feasibility of microwave pressure monitoring through scalp, device integrity over a long period of time, and repeatability of pressure measurements. A distinction between an epidural and sub-dural pressure monitoring techniques is also described. Histo-pathological results obtained upon a long-term device implantation favor the utilization of the sub-dural pressure monitoring method. On the other hand, in-vivo studies illustrate a maximum pressure reading error of 0.8 mm · Hg obtained for a sub-dural device with a capacitive microelectromechanical system sensor compared to 2 mm · Hg obtained for an epidural device with a piezoresistive sensor.
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U2 - 10.1109/TMTT.2008.2004253
DO - 10.1109/TMTT.2008.2004253
M3 - Article
AN - SCOPUS:54049125622
SN - 0018-9480
VL - 56
SP - 2356
EP - 2365
JO - IEEE Transactions on Microwave Theory and Techniques
JF - IEEE Transactions on Microwave Theory and Techniques
IS - 10
M1 - 4631475
ER -