In vitro antitumor activity of Solanum aculeastrum berries on three carcinoma cells

S. Koduru; D. S. Grierson; M. van de Venter; A. J. Afolayan

doi:10.3923/ijcr.2006.397.402

In vitro antitumor activity of Solanum aculeastrum berries on three carcinoma cells

S. Koduru, D. S. Grierson, M. van de Venter, A. J. Afolayan

Department of Surgery

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Solanum aculeastrum is a medicinal plant used by the traditional healers of the Eastern Cape of South Africa, for the treatment of cancers. The antiproliferative activities of this plant were studied in vitro using three human tumour cell lines (HeLa, MCF7 and HT29). Methanolic extracts of the fruits had the highest antiproliferative activity with IC₅₀ between 17.1 and 41.9 μg mL^-1 while the activities of their aqueous extracts ranged between 27.9 and 48.5 μg mL^-1. The leaf extracts had no anticancer activity under the experimental conditions tested. Overall, the HeLa and MCF7 cell lines were much more sensitive to both extracts than HT29 cells.

Original language	English (US)
Pages (from-to)	397-402
Number of pages	6
Journal	International Journal of Cancer Research
Volume	2
Issue number	4
DOIs	https://doi.org/10.3923/ijcr.2006.397.402
State	Published - 2006

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.3923/ijcr.2006.397.402

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abstract = "Solanum aculeastrum is a medicinal plant used by the traditional healers of the Eastern Cape of South Africa, for the treatment of cancers. The antiproliferative activities of this plant were studied in vitro using three human tumour cell lines (HeLa, MCF7 and HT29). Methanolic extracts of the fruits had the highest antiproliferative activity with IC50 between 17.1 and 41.9 μg mL-1 while the activities of their aqueous extracts ranged between 27.9 and 48.5 μg mL-1. The leaf extracts had no anticancer activity under the experimental conditions tested. Overall, the HeLa and MCF7 cell lines were much more sensitive to both extracts than HT29 cells.",

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AU - Grierson, D. S.

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AB - Solanum aculeastrum is a medicinal plant used by the traditional healers of the Eastern Cape of South Africa, for the treatment of cancers. The antiproliferative activities of this plant were studied in vitro using three human tumour cell lines (HeLa, MCF7 and HT29). Methanolic extracts of the fruits had the highest antiproliferative activity with IC50 between 17.1 and 41.9 μg mL-1 while the activities of their aqueous extracts ranged between 27.9 and 48.5 μg mL-1. The leaf extracts had no anticancer activity under the experimental conditions tested. Overall, the HeLa and MCF7 cell lines were much more sensitive to both extracts than HT29 cells.

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In vitro antitumor activity of Solanum aculeastrum berries on three carcinoma cells

Abstract

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