In vitro electrochemistry of biological systems

Kelly L. Adams, Maja Puchades, Andrew G. Ewing

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations


This article reviews recent work involving electrochemical methods for in vitro analysis of biomolecules, with an emphasis on detection and manipulation at and of single cells and cultures of cells. The techniques discussed include constant potential amperometry, chronoamperometry, cellular electroporation, scanning electrochemical microscopy, and microfluidic platforms integrated with electrochemical detection. The principles of these methods are briefly described, followed in most cases with a short description of an analytical or biological application and its significance. The use of electrochemical methods to examine specific mechanistic issues in exocytosis is highlighted, as a great deal of recent work has been devoted to this application.

Original languageEnglish (US)
Pages (from-to)329-355
Number of pages27
JournalAnnual Review of Analytical Chemistry
Issue number1
StatePublished - 2008

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry


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