TY - JOUR
T1 - In vitro growth inhibition of human cancer cells by novel honokiol analogs
AU - Lin, Jyh ming
AU - Prakasha Gowda, A. S.
AU - Sharma, Arun
AU - Amin, Shantu
N1 - Funding Information:
The author thanks the financial support from Penn State Hershey Cancer Institute (J.M.L). This study was supported in part by the NCI Grant R03-CA143999 (A.K.S.). The authors like to thank the Core Research Facilities at College of Medicine, Pennsylvania State University for recording of flow cytometry and NMR facility for NMR spectra. In addition, we appreciate Dr. Kun-Ming Chen for obtaining mass spectra for our compounds.
PY - 2012/5/15
Y1 - 2012/5/15
N2 - Honokiol possesses many pharmacological activities including anti-cancer properties. Here in, we designed and synthesized honokiol analogs that block major honokiol metabolic pathway which may enhance their effectiveness. We studied their cytotoxicity in human cancer cells and evaluated possible mechanism of cell cycle arrest. Two analogs, namely 2 and 4, showed much higher growth inhibitory activity in A549 human lung cancer cells and significant increase of cell population in the G0-G1 phase. Further elucidation of the inhibition mechanism on cell cycle showed that analogs 2 and 4 inhibit both CDK1 and cyclin B1 protien levels in A549 cells.
AB - Honokiol possesses many pharmacological activities including anti-cancer properties. Here in, we designed and synthesized honokiol analogs that block major honokiol metabolic pathway which may enhance their effectiveness. We studied their cytotoxicity in human cancer cells and evaluated possible mechanism of cell cycle arrest. Two analogs, namely 2 and 4, showed much higher growth inhibitory activity in A549 human lung cancer cells and significant increase of cell population in the G0-G1 phase. Further elucidation of the inhibition mechanism on cell cycle showed that analogs 2 and 4 inhibit both CDK1 and cyclin B1 protien levels in A549 cells.
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U2 - 10.1016/j.bmc.2012.03.062
DO - 10.1016/j.bmc.2012.03.062
M3 - Article
C2 - 22533983
AN - SCOPUS:84860460949
SN - 0968-0896
VL - 20
SP - 3202
EP - 3211
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 10
ER -