In vitro growth inhibition of human cancer cells by novel honokiol analogs

Jyh ming Lin; A. S. Prakasha Gowda; Arun Sharma; Shantu Amin

doi:10.1016/j.bmc.2012.03.062

In vitro growth inhibition of human cancer cells by novel honokiol analogs

Jyh ming Lin
, A. S. Prakasha Gowda
, Arun Sharma
, Shantu Amin

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Honokiol possesses many pharmacological activities including anti-cancer properties. Here in, we designed and synthesized honokiol analogs that block major honokiol metabolic pathway which may enhance their effectiveness. We studied their cytotoxicity in human cancer cells and evaluated possible mechanism of cell cycle arrest. Two analogs, namely 2 and 4, showed much higher growth inhibitory activity in A549 human lung cancer cells and significant increase of cell population in the G0-G1 phase. Further elucidation of the inhibition mechanism on cell cycle showed that analogs 2 and 4 inhibit both CDK1 and cyclin B1 protien levels in A549 cells.

Original language	English (US)
Pages (from-to)	3202-3211
Number of pages	10
Journal	Bioorganic and Medicinal Chemistry
Volume	20
Issue number	10
DOIs	https://doi.org/10.1016/j.bmc.2012.03.062
State	Published - May 15 2012

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmc.2012.03.062

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title = "In vitro growth inhibition of human cancer cells by novel honokiol analogs",

abstract = "Honokiol possesses many pharmacological activities including anti-cancer properties. Here in, we designed and synthesized honokiol analogs that block major honokiol metabolic pathway which may enhance their effectiveness. We studied their cytotoxicity in human cancer cells and evaluated possible mechanism of cell cycle arrest. Two analogs, namely 2 and 4, showed much higher growth inhibitory activity in A549 human lung cancer cells and significant increase of cell population in the G0-G1 phase. Further elucidation of the inhibition mechanism on cell cycle showed that analogs 2 and 4 inhibit both CDK1 and cyclin B1 protien levels in A549 cells.",

author = "Lin, \{Jyh ming\} and \{Prakasha Gowda\}, \{A. S.\} and Arun Sharma and Shantu Amin",

note = "Funding Information: The author thanks the financial support from Penn State Hershey Cancer Institute (J.M.L). This study was supported in part by the NCI Grant R03-CA143999 (A.K.S.). The authors like to thank the Core Research Facilities at College of Medicine, Pennsylvania State University for recording of flow cytometry and NMR facility for NMR spectra. In addition, we appreciate Dr. Kun-Ming Chen for obtaining mass spectra for our compounds. ",

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doi = "10.1016/j.bmc.2012.03.062",

language = "English (US)",

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AU - Prakasha Gowda, A. S.

AU - Sharma, Arun

AU - Amin, Shantu

N1 - Funding Information: The author thanks the financial support from Penn State Hershey Cancer Institute (J.M.L). This study was supported in part by the NCI Grant R03-CA143999 (A.K.S.). The authors like to thank the Core Research Facilities at College of Medicine, Pennsylvania State University for recording of flow cytometry and NMR facility for NMR spectra. In addition, we appreciate Dr. Kun-Ming Chen for obtaining mass spectra for our compounds.

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Y1 - 2012/5/15

N2 - Honokiol possesses many pharmacological activities including anti-cancer properties. Here in, we designed and synthesized honokiol analogs that block major honokiol metabolic pathway which may enhance their effectiveness. We studied their cytotoxicity in human cancer cells and evaluated possible mechanism of cell cycle arrest. Two analogs, namely 2 and 4, showed much higher growth inhibitory activity in A549 human lung cancer cells and significant increase of cell population in the G0-G1 phase. Further elucidation of the inhibition mechanism on cell cycle showed that analogs 2 and 4 inhibit both CDK1 and cyclin B1 protien levels in A549 cells.

AB - Honokiol possesses many pharmacological activities including anti-cancer properties. Here in, we designed and synthesized honokiol analogs that block major honokiol metabolic pathway which may enhance their effectiveness. We studied their cytotoxicity in human cancer cells and evaluated possible mechanism of cell cycle arrest. Two analogs, namely 2 and 4, showed much higher growth inhibitory activity in A549 human lung cancer cells and significant increase of cell population in the G0-G1 phase. Further elucidation of the inhibition mechanism on cell cycle showed that analogs 2 and 4 inhibit both CDK1 and cyclin B1 protien levels in A549 cells.

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In vitro growth inhibition of human cancer cells by novel honokiol analogs

Abstract

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