In Vitro Optogenetic Characterization of Neuropeptide Release from Prefrontal Cortical Somatostatin Neurons

Nigel C. Dao; Dakota F. Brockway; Nicole A. Crowley

doi:10.1016/j.neuroscience.2019.08.014

In Vitro Optogenetic Characterization of Neuropeptide Release from Prefrontal Cortical Somatostatin Neurons

Nigel C. Dao
, Dakota F. Brockway
, Nicole A. Crowley

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Somatostatin is a neuropeptide thought to play a role in a variety of neuropsychiatric disorders, and is important for healthy aging and behavioral resiliency. Physiological conditions underlying somatostatin peptidergic release are not well-defined. Using a combination of optogenetic and biochemical approaches in transgenic mice, we demonstrate an assay for the induction and inhibition of somatostatin release in mouse acute brain slices.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	Neuroscience
Volume	419
DOIs	https://doi.org/10.1016/j.neuroscience.2019.08.014
State	Published - Nov 1 2019

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/j.neuroscience.2019.08.014

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abstract = "Somatostatin is a neuropeptide thought to play a role in a variety of neuropsychiatric disorders, and is important for healthy aging and behavioral resiliency. Physiological conditions underlying somatostatin peptidergic release are not well-defined. Using a combination of optogenetic and biochemical approaches in transgenic mice, we demonstrate an assay for the induction and inhibition of somatostatin release in mouse acute brain slices.",

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AU - Crowley, Nicole A.

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AB - Somatostatin is a neuropeptide thought to play a role in a variety of neuropsychiatric disorders, and is important for healthy aging and behavioral resiliency. Physiological conditions underlying somatostatin peptidergic release are not well-defined. Using a combination of optogenetic and biochemical approaches in transgenic mice, we demonstrate an assay for the induction and inhibition of somatostatin release in mouse acute brain slices.

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In Vitro Optogenetic Characterization of Neuropeptide Release from Prefrontal Cortical Somatostatin Neurons

Abstract

All Science Journal Classification (ASJC) codes

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