TY - JOUR
T1 - In vivo micro-CT imaging of liver lesions in small animal models
AU - Martiniova, Lucia
AU - Schimel, Daniel
AU - Lai, Edwin W.
AU - Limpuangthip, Andrea
AU - Kvetnansky, Richard
AU - Pacak, Karel
N1 - Funding Information:
We thank the contributions and assistance of Dr. Arthur S. Tischler for his help and guidance. We thank Dr. Brenda Klaunberg and the intramural shared resources for microCT imaging in the Mouse Imaging Facility. We thank Eli Thompson for his assistance with the animals and Mrs. Evin O’Keeffe for her help with editing. This research was supported (in part) by the Intramural Research Program of the NIH/NICHD and APVV-0148-06 (to R.K.). The authors have no conflict of interest to disclose.
PY - 2010/1
Y1 - 2010/1
N2 - Three-dimensional micro computed tomography (microCT) offers the opportunity to capture images liver structures and lesions in mice with a high spatial resolution. Non-invasive microCT allows for accurate calculation of vessel tortuosity and density, as well as liver lesion volume and distribution. Longitudinal monitoring of liver lesions is also possible. However, distinguishing liver lesions from variations within a normal liver is impossible by microCT without the use of liver- or tumor-specific contrast-enhancing agents. The combination of microCT for morphologic imaging with functional imaging, such as positron emission tomography (PET) or single photon emission tomography (SPECT), offers the opportunity for better abdominal imaging and assessment of structure discrepancies visible by functional imaging. This paper describes methods of current microCT imaging options for imaging of liver lesions compared to other imaging techniques in small animals.
AB - Three-dimensional micro computed tomography (microCT) offers the opportunity to capture images liver structures and lesions in mice with a high spatial resolution. Non-invasive microCT allows for accurate calculation of vessel tortuosity and density, as well as liver lesion volume and distribution. Longitudinal monitoring of liver lesions is also possible. However, distinguishing liver lesions from variations within a normal liver is impossible by microCT without the use of liver- or tumor-specific contrast-enhancing agents. The combination of microCT for morphologic imaging with functional imaging, such as positron emission tomography (PET) or single photon emission tomography (SPECT), offers the opportunity for better abdominal imaging and assessment of structure discrepancies visible by functional imaging. This paper describes methods of current microCT imaging options for imaging of liver lesions compared to other imaging techniques in small animals.
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U2 - 10.1016/j.ymeth.2009.05.016
DO - 10.1016/j.ymeth.2009.05.016
M3 - Review article
C2 - 19520168
AN - SCOPUS:72149091979
SN - 1046-2023
VL - 50
SP - 20
EP - 25
JO - Methods
JF - Methods
IS - 1
ER -